Technology Process of Piperazinone, 1-butyl- (9CI)
There total 5 articles about Piperazinone, 1-butyl- (9CI) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-butyl-3-oxo-piperazine-l-carboxylic acid tert-butyl ester; 1,2-dichloro-ethane; trifluoroacetic acid;
In
dichloromethane;
at 20 ℃;
for 16h;
With
sodium hydroxide;
In
water;
Alkaline aqueous solution;
- Guidance literature:
-
With
Methyl 3-mercaptopropionate; lithium hydroxide;
In
dimethyl sulfoxide; acetonitrile;
at 50 ℃;
for 6h;
DOI:10.1039/c8ra00720a
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
2.1: trialkylamine / dichloromethane / 6.5 h / 0 - 20 °C
3.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 60 °C
3.2: 24 h / 60 °C
4.1: lithium hydroxide; Methyl 3-mercaptopropionate / acetonitrile; dimethyl sulfoxide / 6 h / 50 °C
With
Methyl 3-mercaptopropionate; potassium carbonate; trifluoroacetic acid; lithium hydroxide;
In
dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/c8ra00720a
