[2R,3R,1'S,2'S]-(+)-3-(4-methoxy-phenyl-amino)-N,2,4-trimethyl-N-(2'-phenyl-2'-hydroxy-1'-methyl-ethyl)-pentanamide

Base Information

• Chemical Name: [2R,3R,1'S,2'S]-(+)-3-(4-methoxy-phenyl-amino)-N,2,4-trimethyl-N-(2'-phenyl-2'-hydroxy-1'-methyl-ethyl)-pentanamide
• CAS No.: 392673-62-0
• Molecular Formula: C₂₄H₃₄N₂O₃
• Molecular Weight: 398.546
• Mol file: 392673-62-0.mol

Synonyms:[2R,3R,1'S,2'S]-(+)-3-(4-methoxy-phenyl-amino)-N,2,4-trimethyl-N-(2'-phenyl-2'-hydroxy-1'-methyl-ethyl)-pentanamide

Chemical Property of [2R,3R,1'S,2'S]-(+)-3-(4-methoxy-phenyl-amino)-N,2,4-trimethyl-N-(2'-phenyl-2'-hydroxy-1'-methyl-ethyl)-pentanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [2R,3R,1'S,2'S]-(+)-3-(4-methoxy-phenyl-amino)-N,2,4-trimethyl-N-(2'-phenyl-2'-hydroxy-1'-methyl-ethyl)-pentanamide

There total 2 articles about [2R,3R,1'S,2'S]-(+)-3-(4-methoxy-phenyl-amino)-N,2,4-trimethyl-N-(2'-phenyl-2'-hydroxy-1'-methyl-ethyl)-pentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(E)-N-(4-methoxyphenyl)-2-methylpropan-1-imine (392673-58-4) + N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylpropionamide (159213-03-3) → [2R,3R,1'S,2'S]-(+)-3-(4-methoxy-phenyl-amino)-N,2,4-trimethyl-N-(2'-phenyl-2'-hydroxy-1'-methyl-ethyl)-pentanamide (392673-62-0)

Guidance literature:

N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylpropionamide; With lithium diisopropyl amide; In tetrahydrofuran; at -78 - 20 ℃;

With zinc(II) chloride; In tetrahydrofuran; at -78 ℃; for 1h;

(E)-N-(4-methoxyphenyl)-2-methylpropan-1-imine; In tetrahydrofuran; at 0 ℃; Further stages.;

DOI:10.1021/jo010697m

Reference yield: 85.0%

(4-Methoxy-phenyl)-[2-methyl-prop-(Z)-ylidene]-amine (18169-40-9) + N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylpropionamide (159213-03-3) → [2R,3R,1'S,2'S]-(+)-3-(4-methoxy-phenyl-amino)-N,2,4-trimethyl-N-(2'-phenyl-2'-hydroxy-1'-methyl-ethyl)-pentanamide (392673-62-0)

Guidance literature:

N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylpropionamide; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1h;

With zinc(II) chloride; In tetrahydrofuran; at -78 ℃; for 1h;

(4-Methoxy-phenyl)-[2-methyl-prop-(Z)-ylidene]-amine; In tetrahydrofuran; at 0 ℃; Further stages.;

DOI:10.1055/s-2006-950347

Reference yield: 88.0%

methanol (67-56-1) + [2R,3R,1'S,2'S]-(+)-3-(4-methoxy-phenyl-amino)-N,2,4-trimethyl-N-(2'-phenyl-2'-hydroxy-1'-methyl-ethyl)-pentanamide (392673-62-0) → [2R,3R]-(-)-methyl 3-(4-methoxy-phenyl-amino)-2,4-dimethyl-pentanoate (392673-64-2)

Guidance literature:

[2R,3R,1'S,2'S]-(+)-3-(4-methoxy-phenyl-amino)-N,2,4-trimethyl-N-(2'-phenyl-2'-hydroxy-1'-methyl-ethyl)-pentanamide; With sulfuric acid; In 1,4-dioxane; for 6h; Heating;

methanol; With sulfuric acid; for 6h; Further stages.; Heating;

DOI:10.1021/jo010697m

upstream raw materials:

(E)-N-(4-methoxyphenyl)-2-methylpropan-1-imine

N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylpropionamide

(4-Methoxy-phenyl)-[2-methyl-prop-(Z)-ylidene]-amine

Downstream raw materials:

[2R,3R]-(-)-methyl 3-(4-methoxy-phenyl-amino)-2,4-dimethyl-pentanoate