3-bromo-N-(4-chloro-2-methyl-6-(thiazolidin-2-yl)phenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide

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Chemical Name:3-bromo-N-(4-chloro-2-methyl-6-(thiazolidin-2-yl)phenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide
CAS No.:1373758-75-8
Molecular Formula:C₁₉H₁₆BrCl₂N₅OS
Molecular Weight:513.245
Hs Code.:

Synonyms:3-bromo-N-(4-chloro-2-methyl-6-(thiazolidin-2-yl)phenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide

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Chemical Property of 3-bromo-N-(4-chloro-2-methyl-6-(thiazolidin-2-yl)phenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide

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Technology Process of 3-bromo-N-(4-chloro-2-methyl-6-(thiazolidin-2-yl)phenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide

There total 4 articles about 3-bromo-N-(4-chloro-2-methyl-6-(thiazolidin-2-yl)phenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.7%

: 1373758-65-6
3-bromo-N-(4-chloro-2-formyl-6-methylphenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide

: 156-57-0
2-mercaptoethylamine hydrochloride

: 1373758-75-8
3-bromo-N-(4-chloro-2-methyl-6-(thiazolidin-2-yl)phenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide

Guidance literature:: With potassium acetate; In ethanol; at 20 ℃; for 12h;
DOI:10.1002/cjoc.201180295

Reference yield:

: 775331-65-2
(2-amino-5-chloro-3-methylphenyl)methanol

: 1373758-75-8
3-bromo-N-(4-chloro-2-methyl-6-(thiazolidin-2-yl)phenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: manganese(IV) oxide / dichloromethane / 20 °C

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C

2.2: 2 h / 20 °C

3.1: potassium acetate / ethanol / 12 h / 20 °C

With manganese(IV) oxide; oxalyl dichloride; potassium acetate; N,N-dimethyl-formamide; In ethanol; dichloromethane;
DOI:10.1002/cjoc.201180295

Reference yield:

: 20776-67-4
2-amino-5-chloro-3-methylbenzoic acid

: 1373758-75-8
3-bromo-N-(4-chloro-2-methyl-6-(thiazolidin-2-yl)phenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 5 °C

2.1: manganese(IV) oxide / dichloromethane / 20 °C

3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C

3.2: 2 h / 20 °C

4.1: potassium acetate / ethanol / 12 h / 20 °C

With manganese(IV) oxide; lithium aluminium tetrahydride; oxalyl dichloride; potassium acetate; N,N-dimethyl-formamide; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1002/cjoc.201180295