3-bromo-5-methoxycarbonyl-1-(4-methylbenzenesulfonyl)-2(1H)-pyridone

Base Information

• Chemical Name: 3-bromo-5-methoxycarbonyl-1-(4-methylbenzenesulfonyl)-2(1H)-pyridone
• CAS No.: 398145-63-6
• Molecular Formula: C₁₄H₁₂BrNO₅S
• Molecular Weight: 386.223
• Mol file: 398145-63-6.mol

Synonyms:3-bromo-5-methoxycarbonyl-1-(4-methylbenzenesulfonyl)-2(1H)-pyridone

Chemical Property of 3-bromo-5-methoxycarbonyl-1-(4-methylbenzenesulfonyl)-2(1H)-pyridone

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3-bromo-5-methoxycarbonyl-1-(4-methylbenzenesulfonyl)-2(1H)-pyridone

There total 1 articles about 3-bromo-5-methoxycarbonyl-1-(4-methylbenzenesulfonyl)-2(1H)-pyridone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

p-toluenesulfonyl chloride (98-59-9) + methyl 5-bromo-6-oxo-1,6-dihydropyridine-3-carboxylate (381247-99-0) → 3-bromo-5-methoxycarbonyl-1-(4-methylbenzenesulfonyl)-2(1H)-pyridone (398145-63-6)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at -78 - 30 ℃;

DOI:10.1016/S0040-4020(01)00893-6

Reference yield: 81.0%

2,3-dimethyl-buta-1,3-diene (513-81-5) + 3-bromo-5-methoxycarbonyl-1-(4-methylbenzenesulfonyl)-2(1H)-pyridone (398145-63-6) → 3-bromo-4a,5,8,8a-tetrahydro-cis-4a-methoxycarbonyl-6,7-dimethyl-1-(4-methylbenzenesulfonyl)-2(1H)-quinolone

Guidance literature:

In o-xylene; at 160 ℃; for 96h;

DOI:10.1016/S0040-4020(01)00893-6

Reference yield: 35.0%

3-bromo-5-methoxycarbonyl-1-(4-methylbenzenesulfonyl)-2(1H)-pyridone (398145-63-6) + isoprene (78-79-5,9003-31-0) → 3-bromo-4a,5,8,8a-tetrahydro-cis-4a-methoxycarbonyl-7-methyl-1-(4-methylbenzenesulfonyl)-2(1H)-quinolone

Guidance literature:

In o-xylene; at 160 ℃; for 96h;

DOI:10.1016/S0040-4020(01)00893-6

upstream raw materials:

p-toluenesulfonyl chloride

methyl 5-bromo-6-oxo-1,6-dihydropyridine-3-carboxylate