1--2-acetoxy-3-chloropropane

Base Information

• Chemical Name: 1--2-acetoxy-3-chloropropane
• CAS No.: 143925-21-7
• Molecular Formula: C₁₃H₁₆ClNO₄
• Molecular Weight: 285.727

Synonyms:1--2-acetoxy-3-chloropropane

Chemical Property of 1--2-acetoxy-3-chloropropane

Chemical Property:

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Technology Process of 1--2-acetoxy-3-chloropropane

There total 2 articles about 1--2-acetoxy-3-chloropropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

acetic anhydride (108-24-7) + 1--3-chloropropan-2-ol (115538-83-5) → 1--2-acetoxy-3-chloropropane (143925-21-7)

Guidance literature:

With pyridine; In neat (no solvent); at 30 ℃; for 2h;

DOI:10.1039/c4ra16365f

Reference yield:

2-(4-hydroxyphenyl)acetamide (17194-82-0) + acetyl chloride (75-36-5) + epichlorohydrin (106-89-8,24969-06-0,13403-37-7) → 1--2-acetoxy-3-chloropropane (143925-21-7)

Guidance literature:

With sodium hydroxide; Yield given. Multistep reaction; 1) H₂O, RT, 48 h, 2) 25 deg C;

DOI:10.1021/jo00048a040

Reference yield: 95.0%

1--2-acetoxy-3-chloropropane (143925-21-7) → 1--3-chloropropan-2-ol (115538-83-5)

Guidance literature:

With water; potassium carbonate; In methanol; at 20 ℃; for 2h;

DOI:10.1039/c4ra16365f

upstream raw materials:

2-(4-hydroxyphenyl)acetamide

acetyl chloride

epichlorohydrin

acetic anhydride

Downstream raw materials:

1--3-chloropropan-2-ol

(RS)-atenolol

(+)-(R)-atenolol

(S)-Atenolol

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