tert-butyl 4-(3-(8-(5,6-dimethoxypyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)benzamido)benzoate

Base Information

Chemical Name:tert-butyl 4-(3-(8-(5,6-dimethoxypyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)benzamido)benzoate
CAS No.:1415314-16-7
Molecular Formula:C₃₁H₃₀N₆O₅
Molecular Weight:566.616
Hs Code.:

Synonyms:tert-butyl 4-(3-(8-(5,6-dimethoxypyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)benzamido)benzoate

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Chemical Property of tert-butyl 4-(3-(8-(5,6-dimethoxypyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)benzamido)benzoate

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Technology Process of tert-butyl 4-(3-(8-(5,6-dimethoxypyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)benzamido)benzoate

There total 4 articles about tert-butyl 4-(3-(8-(5,6-dimethoxypyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)benzamido)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1415314-15-6
3-(8-(5,6-dimethoxypyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)benzoic acid

: 18144-47-3
tert-butyl 4-aminobenzoate

: 1415314-16-7
tert-butyl 4-(3-(8-(5,6-dimethoxypyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)benzamido)benzoate

Guidance literature:: With 1-methyl-1H-imidazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 16h;
DOI:10.1021/jm301367c

Reference yield:

: 933190-51-3
8-bromo-6-chloro-imidazo[1,2-b]pyridazine

: 1415314-16-7
tert-butyl 4-(3-(8-(5,6-dimethoxypyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)benzamido)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 15.17 h / 0 - 20 °C

2: XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate / 1,4-dioxane / 1 h / 125 °C / Inert atmosphere; Microwave irradiation

3: water; lithium hydroxide / 1,4-dioxane / 4 h

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-methyl-1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C

With 1-methyl-1H-imidazole; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; water; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; XPhos; In 1,4-dioxane; N,N-dimethyl-formamide; mineral oil; 2: |Buchwald-Hartwig Coupling;
DOI:10.1021/jm301367c

Reference yield:

: 1415314-14-5
ethyl 3-(8-(5,6-dimethoxypyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl) benzoate

: 1415314-16-7
tert-butyl 4-(3-(8-(5,6-dimethoxypyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)benzamido)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: water; lithium hydroxide / 1,4-dioxane / 4 h

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-methyl-1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C

With 1-methyl-1H-imidazole; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm301367c