2-acetyl-3-ethoxy-N-{4-[(pyrimidin-2-ylamino)sulfonyl]phenyl}acrylamide

Base Information

• Chemical Name: 2-acetyl-3-ethoxy-N-{4-[(pyrimidin-2-ylamino)sulfonyl]phenyl}acrylamide
• CAS No.: 1100799-36-7
• Molecular Formula: C₁₇H₁₈N₄O₅S
• Molecular Weight: 390.42

Synonyms:2-acetyl-3-ethoxy-N-{4-[(pyrimidin-2-ylamino)sulfonyl]phenyl}acrylamide

Chemical Property of 2-acetyl-3-ethoxy-N-{4-[(pyrimidin-2-ylamino)sulfonyl]phenyl}acrylamide

Chemical Property:

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Technology Process of 2-acetyl-3-ethoxy-N-{4-[(pyrimidin-2-ylamino)sulfonyl]phenyl}acrylamide

There total 1 articles about 2-acetyl-3-ethoxy-N-{4-[(pyrimidin-2-ylamino)sulfonyl]phenyl}acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

orthoformic acid triethyl ester (122-51-0) + 3-oxo-N-{4-[(pyrimidin-2-ylamino)sulphonyl]phenyl}butanamide (134477-88-6) → 2-acetyl-3-ethoxy-N-{4-[(pyrimidin-2-ylamino)sulfonyl]phenyl}acrylamide (1100799-36-7)

Guidance literature:

In acetic anhydride; for 4h; Reflux;

DOI:10.1002/jhet.5570450641

Reference yield: 62.0%

2-acetyl-3-ethoxy-N-{4-[(pyrimidin-2-ylamino)sulfonyl]phenyl}acrylamide (1100799-36-7) + phenylhydrazine (100-63-0) → N-{4-[(pyrimidin-2-ylamino)sulfonyl]phenyl}-5-methyl-N,1-diphenyl-1H-pyrazole-4-carbohydrazonamide (1100799-32-3)

Guidance literature:

In ethanol; for 8h; Reflux;

DOI:10.1002/jhet.5570450641

Reference yield: 54.0%

2-acetyl-3-ethoxy-N-{4-[(pyrimidin-2-ylamino)sulfonyl]phenyl}acrylamide (1100799-36-7) → 3-methyl-N-{4-[(pyrimidin-2-ylamino)sulfonyl]phenyl}-1H-pyrazole-4-carbohydrazonamide (1100799-35-6)

Guidance literature:

With hydrazine hydrate; In ethanol; for 8h; Reflux;

DOI:10.1002/jhet.5570450641

upstream raw materials:

orthoformic acid triethyl ester

3-oxo-N-{4-[(pyrimidin-2-ylamino)sulphonyl]phenyl}butanamide

Downstream raw materials:

3-methyl-N-{4-[(pyrimidin-2-ylamino)sulfonyl]phenyl}-1H-pyrazole-4-carbohydrazonamide

5-cyano-2-methyl-N-{4-[(pyrimidin-2-ylamino)sulfonyl]phenyl}-6-thioxo-1,6-dihydropyridine-3-carboxamide

4-(3,5-diacetyl-6-hydroxy-2-oxo-2H-pyridin-1-yl)-N-pyrimidin-2-ylbenzene-sulfonamide

5-acetyl-2-amino-6-oxo-1-{4-[(pyrimidin-2-ylamino)sulfonyl]-phenyl}-1,6-dihydropyrimidine-3-carboxylic acid ethyl ester

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