N-(2-(benzyloxy)-5-methoxybenzyl)-2-fluoro-N-(2-phenoxyphenyl)acetamide

Base Information

• Chemical Name: N-(2-(benzyloxy)-5-methoxybenzyl)-2-fluoro-N-(2-phenoxyphenyl)acetamide
• CAS No.: 1334484-12-6
• Molecular Formula: C₂₉H₂₆FNO₄
• Molecular Weight: 471.528
• Mol file: 1334484-12-6.mol

Synonyms:N-(2-(benzyloxy)-5-methoxybenzyl)-2-fluoro-N-(2-phenoxyphenyl)acetamide

Chemical Property of N-(2-(benzyloxy)-5-methoxybenzyl)-2-fluoro-N-(2-phenoxyphenyl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-(benzyloxy)-5-methoxybenzyl)-2-fluoro-N-(2-phenoxyphenyl)acetamide

There total 10 articles about N-(2-(benzyloxy)-5-methoxybenzyl)-2-fluoro-N-(2-phenoxyphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

N-(2-(benzyloxy)-5-methoxybenzyl)-2-bromo-N-(2-phenoxyphenyl)acetamide (1334484-11-5) → N-(2-(benzyloxy)-5-methoxybenzyl)-2-fluoro-N-(2-phenoxyphenyl)acetamide (1334484-12-6)

Guidance literature:

With potassium fluoride; In diethylene glycol; at 150 ℃; for 5h;

DOI:10.1016/j.steroids.2011.06.012

Reference yield: 48.0%

2-fluoro-N-(2-phenoxyphenyl)acetamide (1104493-14-2) + (2-benzyloxy-5-methoxybenzyl)-triphenylphosphonium bromide → N-(2-(benzyloxy)-5-methoxybenzyl)-2-fluoro-N-(2-phenoxyphenyl)acetamide (1334484-12-6)

Guidance literature:

2-fluoro-N-(2-phenoxyphenyl)acetamide; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃;

(2-benzyloxy-5-methoxybenzyl)-triphenylphosphonium bromide; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 4h;

DOI:10.1016/j.steroids.2011.06.012

Reference yield:

2-benzyloxy-5-methoxybenzaldehyde (56979-57-8) → N-(2-(benzyloxy)-5-methoxybenzyl)-2-fluoro-N-(2-phenoxyphenyl)acetamide (1334484-12-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 4 h / 20 - 95 °C / Inert atmosphere

2: sodium tetrahydroborate / methanol / 0 - 20 °C / Inert atmosphere

3: triethylamine / dichloromethane / 0 - 20 °C

4: potassium fluoride / diethylene glycol / 5 h / 150 °C

With potassium fluoride; sodium tetrahydroborate; triethylamine; In methanol; dichloromethane; diethylene glycol;

DOI:10.1016/j.steroids.2011.06.012

upstream raw materials:

(2-(benzyloxy)-5-methoxyphenyl)methanol

2-hydroxy-5-methoxybenzaldehyde

2-fluoro-N-(2-phenoxyphenyl)acetamide

N-(2-(benzyloxy)-5-methoxybenzyl)-2-bromo-N-(2-phenoxyphenyl)acetamide

Downstream raw materials:

2-fluoro-N-(2-hydroxy-5-methoxybenzyl)-N-(2-phenoxyphenyl)-acetamide