1-(4-chlorophenyl)-2-(3-(trifluoromethyl)phenyl)ethan-1-one

Base Information

• Chemical Name: 1-(4-chlorophenyl)-2-(3-(trifluoromethyl)phenyl)ethan-1-one
• CAS No.: 1097726-09-4
• Molecular Formula: C₁₅H₁₀ClF₃O
• Molecular Weight: 298.692
• Mol file: 1097726-09-4.mol

Synonyms:1-(4-chlorophenyl)-2-(3-(trifluoromethyl)phenyl)ethan-1-one

Chemical Property of 1-(4-chlorophenyl)-2-(3-(trifluoromethyl)phenyl)ethan-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-chlorophenyl)-2-(3-(trifluoromethyl)phenyl)ethan-1-one

There total 2 articles about 1-(4-chlorophenyl)-2-(3-(trifluoromethyl)phenyl)ethan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-chloro-benzoyl chloride (122-01-0) + 3-Trifluoromethylbenzyl chloride (705-29-3) → 1-(4-chlorophenyl)-2-(3-(trifluoromethyl)phenyl)ethan-1-one (1097726-09-4)

Guidance literature:

3-Trifluoromethylbenzyl chloride; With magnesium; lithium chloride; zinc(II) chloride; In tetrahydrofuran; at 25 ℃; for 0.5h; Inert atmosphere;

With copper(I) cyanide di(lithium chloride); In tetrahydrofuran; at -20 ℃; for 0.25h; Inert atmosphere;

4-chloro-benzoyl chloride; In tetrahydrofuran; at 25 ℃; for 1h; Inert atmosphere;

DOI:10.1039/b812396a

Reference yield: 71.0%

C8H6ClF3Zn*LiCl*MgCl2 + 4-chloro-benzoyl chloride (122-01-0) → 1-(4-chlorophenyl)-2-(3-(trifluoromethyl)phenyl)ethan-1-one (1097726-09-4)

Guidance literature:

With iron(II) chloride; In tetrahydrofuran; at 25 ℃; for 0.5h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.orglett.6b01677

upstream raw materials:

4-chloro-benzoyl chloride

3-Trifluoromethylbenzyl chloride