2-hydroxymethylcyclopropanesulfonic acid [4,5-difluoro-6-(2-fluoro-4-iodophenylamino)-benzofuran-7-yl]-amide

Base Information

Chemical Name:2-hydroxymethylcyclopropanesulfonic acid [4,5-difluoro-6-(2-fluoro-4-iodophenylamino)-benzofuran-7-yl]-amide
CAS No.:1311401-05-4
Molecular Formula:C₁₈H₁₄F₃IN₂O₄S
Molecular Weight:538.286
Hs Code.:

Synonyms:2-hydroxymethylcyclopropanesulfonic acid [4,5-difluoro-6-(2-fluoro-4-iodophenylamino)-benzofuran-7-yl]-amide

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Chemical Property of 2-hydroxymethylcyclopropanesulfonic acid [4,5-difluoro-6-(2-fluoro-4-iodophenylamino)-benzofuran-7-yl]-amide

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Technology Process of 2-hydroxymethylcyclopropanesulfonic acid [4,5-difluoro-6-(2-fluoro-4-iodophenylamino)-benzofuran-7-yl]-amide

There total 9 articles about 2-hydroxymethylcyclopropanesulfonic acid [4,5-difluoro-6-(2-fluoro-4-iodophenylamino)-benzofuran-7-yl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1311401-82-7
2-(benzyloxymethyl)-N-(4,5-difluoro-6-(2-fluoro-4-iodophenylamino)benzofuran-7-yl)cyclopropane-1-sulfonamide

: 1311401-05-4
2-hydroxymethylcyclopropanesulfonic acid [4,5-difluoro-6-(2-fluoro-4-iodophenylamino)-benzofuran-7-yl]-amide

Guidance literature:: 2-(benzyloxymethyl)-N-(4,5-difluoro-6-(2-fluoro-4-iodophenylamino)benzofuran-7-yl)cyclopropane-1-sulfonamide; With boron trichloride; In dichloromethane; at -75 - 35 ℃;

With sodium hydrogencarbonate; In dichloromethane;

Reference yield:

: 314-41-0
1,2,3,5-tetrafluoro-4-nitrobenzene

: 1311401-05-4
2-hydroxymethylcyclopropanesulfonic acid [4,5-difluoro-6-(2-fluoro-4-iodophenylamino)-benzofuran-7-yl]-amide

Guidance literature:: Multi-step reaction with 8 steps

1.1: lithium hexamethyldisilazane / hexane; tetrahydrofuran / 1 h / -78 °C

1.2: 1 h / 20 °C

2.1: sodium hydride / tetrahydrofuran / 0 - 40 °C

2.2: 0 - 20 °C

3.1: acetic acid

3.2: 0 - 40 °C

4.1: hydrogenchloride / water; tetrahydrofuran

4.2: 0 - 40 °C

5.1: dichloromethane / 20 - 40 °C

6.1: triethylamine / dichloromethane / 0 °C

6.2: 12 h / 20 - 40 °C

7.1: potassium trimethylsilonate / tetrahydrofuran / 0 - 40 °C

8.1: boron trichloride / dichloromethane / -75 - 35 °C

With hydrogenchloride; potassium trimethylsilonate; boron trichloride; sodium hydride; acetic acid; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; dichloromethane; water;

Reference yield:

: 29632-74-4
2-fluro-4-iodoaniline

: 1311401-05-4
2-hydroxymethylcyclopropanesulfonic acid [4,5-difluoro-6-(2-fluoro-4-iodophenylamino)-benzofuran-7-yl]-amide

Guidance literature:: Multi-step reaction with 8 steps

1.1: lithium hexamethyldisilazane / hexane; tetrahydrofuran / 1 h / -78 °C

1.2: 1 h / 20 °C

2.1: sodium hydride / tetrahydrofuran / 0 - 40 °C

2.2: 0 - 20 °C

3.1: acetic acid

3.2: 0 - 40 °C

4.1: hydrogenchloride / water; tetrahydrofuran

4.2: 0 - 40 °C

5.1: dichloromethane / 20 - 40 °C

6.1: triethylamine / dichloromethane / 0 °C

6.2: 12 h / 20 - 40 °C

7.1: potassium trimethylsilonate / tetrahydrofuran / 0 - 40 °C

8.1: boron trichloride / dichloromethane / -75 - 35 °C

With hydrogenchloride; potassium trimethylsilonate; boron trichloride; sodium hydride; acetic acid; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; dichloromethane; water;