{2-[4-(tert-Butyl-diphenyl-silanyloxymethyl)-2-methoxy-5-(2-methoxy-ethoxymethoxy)-benzyl]-4-hydroxy-phenoxy}-acetonitrile

Base Information

Chemical Name:{2-[4-(tert-Butyl-diphenyl-silanyloxymethyl)-2-methoxy-5-(2-methoxy-ethoxymethoxy)-benzyl]-4-hydroxy-phenoxy}-acetonitrile
CAS No.:195601-89-9
Molecular Formula:C₃₇H₄₃NO₇Si
Molecular Weight:641.836
Hs Code.:

Synonyms:{2-[4-(tert-Butyl-diphenyl-silanyloxymethyl)-2-methoxy-5-(2-methoxy-ethoxymethoxy)-benzyl]-4-hydroxy-phenoxy}-acetonitrile

Suppliers and Price of {2-[4-(tert-Butyl-diphenyl-silanyloxymethyl)-2-methoxy-5-(2-methoxy-ethoxymethoxy)-benzyl]-4-hydroxy-phenoxy}-acetonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of {2-[4-(tert-Butyl-diphenyl-silanyloxymethyl)-2-methoxy-5-(2-methoxy-ethoxymethoxy)-benzyl]-4-hydroxy-phenoxy}-acetonitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of {2-[4-(tert-Butyl-diphenyl-silanyloxymethyl)-2-methoxy-5-(2-methoxy-ethoxymethoxy)-benzyl]-4-hydroxy-phenoxy}-acetonitrile

There total 12 articles about {2-[4-(tert-Butyl-diphenyl-silanyloxymethyl)-2-methoxy-5-(2-methoxy-ethoxymethoxy)-benzyl]-4-hydroxy-phenoxy}-acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 195601-86-6
Benzoic acid 3-[4-(tert-butyl-diphenyl-silanyloxymethyl)-2-methoxy-5-(2-methoxy-ethoxymethoxy)-benzyl]-4-cyanomethoxy-phenyl ester

: 195601-89-9
{2-[4-(tert-Butyl-diphenyl-silanyloxymethyl)-2-methoxy-5-(2-methoxy-ethoxymethoxy)-benzyl]-4-hydroxy-phenoxy}-acetonitrile

Guidance literature:: With methanol; sodium methylate; In tetrahydrofuran; for 0.333333h;
DOI:10.1021/jm970251r

Reference yield:

: 1194-98-5
2,5-Dihydroxybenzaldehyde

: 195601-89-9
{2-[4-(tert-Butyl-diphenyl-silanyloxymethyl)-2-methoxy-5-(2-methoxy-ethoxymethoxy)-benzyl]-4-hydroxy-phenoxy}-acetonitrile

Guidance literature:: Multi-step reaction with 8 steps

1: 98 percent / Et₃N / CH₂Cl₂ / Ambient temperature

2: 82 percent / NaH, DMPU / tetrahydrofuran / 1.5 h / Ambient temperature

3: NaBH₄ / tetrahydrofuran; bis-(2-methoxy-ethyl) ether / 1.5 h

4: imidazole / CH₂Cl₂ / 1.5 h

5: 81 percent / morpholime, N-iodosuccinamide (NIS) / CH₂Cl₂ / 3 h / 0 - 20 °C

6: 51 percent / NaH, DMPU / tetrahydrofuran / 1.5 h / Ambient temperature

7: 1.) Zn, 1,2-dibromoethane, 2.) tetrakis(triphenylphosphine)palladium / 1.) THF, 0-5 deg C, 2.) THF, 65 deg C, 5 h

8: 86 percent / NaOMe, MeOH / tetrahydrofuran / 0.33 h

With morpholine; 1H-imidazole; methanol; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-Iodosuccinamide; sodium methylate; sodium hydride; ethylene dibromide; triethylamine; zinc; In tetrahydrofuran; dichloromethane; diethylene glycol dimethyl ether;
DOI:10.1021/jm970251r

Reference yield:

: 147067-92-3
2-hydroxy-5-benzoyloxybenzaldehyde

: 195601-89-9
{2-[4-(tert-Butyl-diphenyl-silanyloxymethyl)-2-methoxy-5-(2-methoxy-ethoxymethoxy)-benzyl]-4-hydroxy-phenoxy}-acetonitrile

Guidance literature:: Multi-step reaction with 7 steps

1: 82 percent / NaH, DMPU / tetrahydrofuran / 1.5 h / Ambient temperature

2: NaBH₄ / tetrahydrofuran; bis-(2-methoxy-ethyl) ether / 1.5 h

3: imidazole / CH₂Cl₂ / 1.5 h

4: 81 percent / morpholime, N-iodosuccinamide (NIS) / CH₂Cl₂ / 3 h / 0 - 20 °C

5: 51 percent / NaH, DMPU / tetrahydrofuran / 1.5 h / Ambient temperature

6: 1.) Zn, 1,2-dibromoethane, 2.) tetrakis(triphenylphosphine)palladium / 1.) THF, 0-5 deg C, 2.) THF, 65 deg C, 5 h

7: 86 percent / NaOMe, MeOH / tetrahydrofuran / 0.33 h

With morpholine; 1H-imidazole; methanol; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-Iodosuccinamide; sodium methylate; sodium hydride; ethylene dibromide; zinc; In tetrahydrofuran; dichloromethane; diethylene glycol dimethyl ether;
DOI:10.1021/jm970251r