Technology Process of trans-phenyl 3,4,4a,5,6,8a-hexahydro-4a-(3-methoxyphenyl)-6-oxo-2(1H)-isoquinolinecarboxylate
There total 5 articles about trans-phenyl 3,4,4a,5,6,8a-hexahydro-4a-(3-methoxyphenyl)-6-oxo-2(1H)-isoquinolinecarboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) n-BuLi, 3.) NaI, K2CO3
2: 83 percent / 1.) MeSO3H, 2.) NaBH4 / methanol / 1.) from -60 to 25 deg C, 5 min, 2.) RT, 30 min
3: 88 percent / i-Pr2NEt / 1,2-dichloro-ethane / 1.5 h / Heating
4: 94 percent / OsO4, NaIO4 / tetrahydrofuran; H2O / 4 h / Ambient temperature
5: 1.) PhSeCl, concd HCl, 2.) 30percent H2O2, pyridine / 1.) EtOAc, RT, 30 min, 2.) CH2Cl2, RT, 45 min
With
pyridine; hydrogenchloride; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; n-butyllithium; Phenylselenyl chloride; methanesulfonic acid; dihydrogen peroxide; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium iodide;
In
tetrahydrofuran; methanol; water; 1,2-dichloro-ethane;
DOI:10.1021/jm00079a005
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 88 percent / i-Pr2NEt / 1,2-dichloro-ethane / 1.5 h / Heating
2: 94 percent / OsO4, NaIO4 / tetrahydrofuran; H2O / 4 h / Ambient temperature
3: 1.) PhSeCl, concd HCl, 2.) 30percent H2O2, pyridine / 1.) EtOAc, RT, 30 min, 2.) CH2Cl2, RT, 45 min
With
pyridine; hydrogenchloride; sodium periodate; osmium(VIII) oxide; Phenylselenyl chloride; dihydrogen peroxide; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; water; 1,2-dichloro-ethane;
DOI:10.1021/jm00079a005
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 83 percent / 1.) MeSO3H, 2.) NaBH4 / methanol / 1.) from -60 to 25 deg C, 5 min, 2.) RT, 30 min
2: 88 percent / i-Pr2NEt / 1,2-dichloro-ethane / 1.5 h / Heating
3: 94 percent / OsO4, NaIO4 / tetrahydrofuran; H2O / 4 h / Ambient temperature
4: 1.) PhSeCl, concd HCl, 2.) 30percent H2O2, pyridine / 1.) EtOAc, RT, 30 min, 2.) CH2Cl2, RT, 45 min
With
pyridine; hydrogenchloride; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; Phenylselenyl chloride; methanesulfonic acid; dihydrogen peroxide; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; methanol; water; 1,2-dichloro-ethane;
DOI:10.1021/jm00079a005
