4-(2,4-dichlorophenyl)-8-(1H-pyrrol-1-yl)-4,5-dihydropyrrolo[1,2-a]quinoxaline

Base Information

Chemical Name:4-(2,4-dichlorophenyl)-8-(1H-pyrrol-1-yl)-4,5-dihydropyrrolo[1,2-a]quinoxaline
CAS No.:1360546-60-6
Molecular Formula:C₂₁H₁₅Cl₂N₃
Molecular Weight:380.276
Hs Code.:

Synonyms:4-(2,4-dichlorophenyl)-8-(1H-pyrrol-1-yl)-4,5-dihydropyrrolo[1,2-a]quinoxaline

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Chemical Property of 4-(2,4-dichlorophenyl)-8-(1H-pyrrol-1-yl)-4,5-dihydropyrrolo[1,2-a]quinoxaline

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Technology Process of 4-(2,4-dichlorophenyl)-8-(1H-pyrrol-1-yl)-4,5-dihydropyrrolo[1,2-a]quinoxaline

There total 3 articles about 4-(2,4-dichlorophenyl)-8-(1H-pyrrol-1-yl)-4,5-dihydropyrrolo[1,2-a]quinoxaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1360546-50-4
2,4-di(pyrrol-1-yl)phenylamine

: 874-42-0
2,4-dichlorobenzaldeyhde

: 1360546-60-6
4-(2,4-dichlorophenyl)-8-(1H-pyrrol-1-yl)-4,5-dihydropyrrolo[1,2-a]quinoxaline

Guidance literature:: With 1,2,3-Benzotriazole; aluminum (III) chloride; In tetrahydrofuran; at 25 ℃; Inert atmosphere;
DOI:10.1002/ejoc.201101013

Reference yield:

: 1360546-48-0
C₁₄H₁₁N₃O₂

: 1360546-60-6
4-(2,4-dichlorophenyl)-8-(1H-pyrrol-1-yl)-4,5-dihydropyrrolo[1,2-a]quinoxaline

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / ethanol / 25 °C / 2327.23 Torr

2: 1,2,3-Benzotriazole; aluminum (III) chloride / tetrahydrofuran / 25 °C / Inert atmosphere

With 1,2,3-Benzotriazole; aluminum (III) chloride; palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; ethanol; 2: Pictet-Spengler cyclisation;
DOI:10.1002/ejoc.201101013

Reference yield:

: 446-35-5
2,4-Difluoronitrobenzene

: 1360546-60-6
4-(2,4-dichlorophenyl)-8-(1H-pyrrol-1-yl)-4,5-dihydropyrrolo[1,2-a]quinoxaline

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / dimethyl sulfoxide / 25 °C

2: palladium 10% on activated carbon; hydrogen / ethanol / 25 °C / 2327.23 Torr

3: 1,2,3-Benzotriazole; aluminum (III) chloride / tetrahydrofuran / 25 °C / Inert atmosphere

With 1,2,3-Benzotriazole; aluminum (III) chloride; palladium 10% on activated carbon; hydrogen; sodium hydroxide; In tetrahydrofuran; ethanol; dimethyl sulfoxide; 3: Pictet-Spengler cyclisation;
DOI:10.1002/ejoc.201101013