2-{2,2-dimethyl-6-[6-(3-phenyl-ureido)-purin-9-yl]-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethoxy}-nicotinic acid

Base Information

Chemical Name:2-{2,2-dimethyl-6-[6-(3-phenyl-ureido)-purin-9-yl]-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethoxy}-nicotinic acid
CAS No.:851046-19-0
Molecular Formula:C₂₆H₂₅N₇O₇
Molecular Weight:547.527
Hs Code.:

Synonyms:2-{2,2-dimethyl-6-[6-(3-phenyl-ureido)-purin-9-yl]-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethoxy}-nicotinic acid

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Chemical Property of 2-{2,2-dimethyl-6-[6-(3-phenyl-ureido)-purin-9-yl]-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethoxy}-nicotinic acid

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Technology Process of 2-{2,2-dimethyl-6-[6-(3-phenyl-ureido)-purin-9-yl]-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethoxy}-nicotinic acid

There total 3 articles about 2-{2,2-dimethyl-6-[6-(3-phenyl-ureido)-purin-9-yl]-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethoxy}-nicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 2942-59-8
2-chloronicotinic acid

: 1-[9-(6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl]-3-phenyl-urea

: 851046-19-0
2-{2,2-dimethyl-6-[6-(3-phenyl-ureido)-purin-9-yl]-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethoxy}-nicotinic acid

Guidance literature:: 1-[9-(6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl]-3-phenyl-urea; With potassium tert-butylate; In N,N-dimethyl-formamide; at 23 ℃; for 0.5h;

2-chloronicotinic acid; In N,N-dimethyl-formamide; at 23 ℃; for 15h;

Reference yield:

: 851046-14-5
5'-O-triisopropylsilyl-2',3'-di-O-isopropylidene adenosine

: 851046-19-0
2-{2,2-dimethyl-6-[6-(3-phenyl-ureido)-purin-9-yl]-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethoxy}-nicotinic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene / 16 h / 25 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h

3.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.5 h / 23 °C

3.2: 15 h / 23 °C

With potassium tert-butylate; tetrabutyl ammonium fluoride; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;

Reference yield:

: 58-61-7
adenosine

: 851046-19-0
2-{2,2-dimethyl-6-[6-(3-phenyl-ureido)-purin-9-yl]-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethoxy}-nicotinic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: Amberlyst 15H+ resin / N,N-dimethyl-formamide / 3 h / 55 °C

2.1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 23 °C

3.1: toluene / 16 h / 25 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h

5.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.5 h / 23 °C

5.2: 15 h / 23 °C

With 1H-imidazole; potassium tert-butylate; tetrabutyl ammonium fluoride; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;