2-(1-(6-fluoro-4-(2-hydroxyethylsulfinyl)-3-phenylquinolin-2-yl)ethyl)isoindoline-1,3-dione

Base Information

Chemical Name:2-(1-(6-fluoro-4-(2-hydroxyethylsulfinyl)-3-phenylquinolin-2-yl)ethyl)isoindoline-1,3-dione
CAS No.:1259522-02-5
Molecular Formula:C₂₇H₂₁FN₂O₄S
Molecular Weight:488.539
Hs Code.:

Synonyms:2-(1-(6-fluoro-4-(2-hydroxyethylsulfinyl)-3-phenylquinolin-2-yl)ethyl)isoindoline-1,3-dione

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Chemical Property of 2-(1-(6-fluoro-4-(2-hydroxyethylsulfinyl)-3-phenylquinolin-2-yl)ethyl)isoindoline-1,3-dione

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Technology Process of 2-(1-(6-fluoro-4-(2-hydroxyethylsulfinyl)-3-phenylquinolin-2-yl)ethyl)isoindoline-1,3-dione

There total 12 articles about 2-(1-(6-fluoro-4-(2-hydroxyethylsulfinyl)-3-phenylquinolin-2-yl)ethyl)isoindoline-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1259522-06-9
2-(1-(4-(2-(tert-butyldimethylsilyloxy)ethylthio)-6-fluoro-3-phenylquinolin-2-yl)ethyl)isoindoline-1,3-dione

: 1259522-02-5
2-(1-(6-fluoro-4-(2-hydroxyethylsulfinyl)-3-phenylquinolin-2-yl)ethyl)isoindoline-1,3-dione

Guidance literature:: With oxone; In tetrahydrofuran; water; at 20 ℃; for 16h;
DOI:10.1016/j.bmcl.2015.01.001

Reference yield:

: 371-40-4
4-fluoroaniline

: 1259522-02-5
2-(1-(6-fluoro-4-(2-hydroxyethylsulfinyl)-3-phenylquinolin-2-yl)ethyl)isoindoline-1,3-dione

Guidance literature:: Multi-step reaction with 10 steps

1: pyridine / 16 h / 130 °C

2: lithium hydroxide / tetrahydrofuran / 2 h

3: polyphosphoric acid / 2 h / 130 °C

4: trichlorophosphate / 2 h / 100 °C

5: potassium carbonate; 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex / tetrahydrofuran / 6 h / Reflux

6: N,N-dimethyl-formamide / 16 h / 100 °C

7: 1H-imidazole / N,N-dimethyl-formamide / 2 h

8: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 3 h / Reflux

9: N,N-dimethyl-formamide / 16 h / 60 °C

10: oxone / tetrahydrofuran; water / 16 h / 20 °C

With pyridine; 1H-imidazole; N-Bromosuccinimide; 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; potassium carbonate; lithium hydroxide; trichlorophosphate; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2015.01.001

Reference yield:

: 1259521-34-0
4-chloro-2-ethyl-6-fluoro-3-phenylquinoline

: 1259522-02-5
2-(1-(6-fluoro-4-(2-hydroxyethylsulfinyl)-3-phenylquinolin-2-yl)ethyl)isoindoline-1,3-dione

Guidance literature:: Multi-step reaction with 5 steps

1: N,N-dimethyl-formamide / 16 h / 100 °C

2: 1H-imidazole / N,N-dimethyl-formamide / 2 h

3: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 3 h / Reflux

4: N,N-dimethyl-formamide / 16 h / 60 °C

5: oxone / tetrahydrofuran; water / 16 h / 20 °C

With 1H-imidazole; N-Bromosuccinimide; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2015.01.001