2-(1-(4-(2-(tert-butyldimethylsilyloxy)ethylthio)-6-fluoro-3-phenylquinolin-2-yl)ethyl)isoindoline-1,3-dione

Base Information

Chemical Name:2-(1-(4-(2-(tert-butyldimethylsilyloxy)ethylthio)-6-fluoro-3-phenylquinolin-2-yl)ethyl)isoindoline-1,3-dione
CAS No.:1259522-06-9
Molecular Formula:C₃₃H₃₅FN₂O₃SSi
Molecular Weight:586.802
Hs Code.:

Synonyms:2-(1-(4-(2-(tert-butyldimethylsilyloxy)ethylthio)-6-fluoro-3-phenylquinolin-2-yl)ethyl)isoindoline-1,3-dione

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Chemical Property of 2-(1-(4-(2-(tert-butyldimethylsilyloxy)ethylthio)-6-fluoro-3-phenylquinolin-2-yl)ethyl)isoindoline-1,3-dione

Chemical Property:

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Technology Process of 2-(1-(4-(2-(tert-butyldimethylsilyloxy)ethylthio)-6-fluoro-3-phenylquinolin-2-yl)ethyl)isoindoline-1,3-dione

There total 11 articles about 2-(1-(4-(2-(tert-butyldimethylsilyloxy)ethylthio)-6-fluoro-3-phenylquinolin-2-yl)ethyl)isoindoline-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1259522-05-8
2-(1-bromoethyl)-4-(2-(tert-butyldimethylsilyloxy)ethylthio)-6-fluoro-3-phenylquinoline

: 1074-82-4
potassium phtalimide

: 1259522-06-9
2-(1-(4-(2-(tert-butyldimethylsilyloxy)ethylthio)-6-fluoro-3-phenylquinolin-2-yl)ethyl)isoindoline-1,3-dione

Guidance literature:: In N,N-dimethyl-formamide; at 60 ℃; for 2h;

Reference yield:

: 371-40-4
4-fluoroaniline

: 1259522-06-9
2-(1-(4-(2-(tert-butyldimethylsilyloxy)ethylthio)-6-fluoro-3-phenylquinolin-2-yl)ethyl)isoindoline-1,3-dione

Guidance literature:: Multi-step reaction with 6 steps

1: trichlorophosphate / 60 °C

2: potassium carbonate; 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex / tetrahydrofuran / 6 h / Reflux

3: N,N-dimethyl-formamide / 16 h / 100 °C

4: 1H-imidazole / N,N-dimethyl-formamide / 2 h

5: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 3 h / Reflux

6: N,N-dimethyl-formamide / 16 h / 60 °C

With 1H-imidazole; N-Bromosuccinimide; 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; potassium carbonate; trichlorophosphate; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2015.01.001

Reference yield:

: 1259521-34-0
4-chloro-2-ethyl-6-fluoro-3-phenylquinoline

: 1259522-06-9
2-(1-(4-(2-(tert-butyldimethylsilyloxy)ethylthio)-6-fluoro-3-phenylquinolin-2-yl)ethyl)isoindoline-1,3-dione

Guidance literature:: Multi-step reaction with 4 steps

1: N,N-dimethyl-formamide / 16 h / 100 °C

2: 1H-imidazole / N,N-dimethyl-formamide / 2 h

3: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 3 h / Reflux

4: N,N-dimethyl-formamide / 16 h / 60 °C

With 1H-imidazole; N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2015.01.001