ethyl N-[3-(1,1-biphenyl-4-yl)-4-cyano-1-phenyl-1H-pyrazol-5-yl]imidoformate

Base Information

• Chemical Name: ethyl N-[3-(1,1-biphenyl-4-yl)-4-cyano-1-phenyl-1H-pyrazol-5-yl]imidoformate
• CAS No.: 1448231-29-5
• Molecular Formula: C₂₅H₂₀N₄O
• Molecular Weight: 392.46

Synonyms:ethyl N-[3-(1,1-biphenyl-4-yl)-4-cyano-1-phenyl-1H-pyrazol-5-yl]imidoformate

Chemical Property of ethyl N-[3-(1,1-biphenyl-4-yl)-4-cyano-1-phenyl-1H-pyrazol-5-yl]imidoformate

Chemical Property:

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Technology Process of ethyl N-[3-(1,1-biphenyl-4-yl)-4-cyano-1-phenyl-1H-pyrazol-5-yl]imidoformate

There total 5 articles about ethyl N-[3-(1,1-biphenyl-4-yl)-4-cyano-1-phenyl-1H-pyrazol-5-yl]imidoformate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

5-amino-3-(1,1-biphenyl-4-yl)-1-phenyl-1H-pyrazole-4-carbonitrile (1448231-28-4) + orthoformic acid triethyl ester (122-51-0) → ethyl N-[3-(1,1-biphenyl-4-yl)-4-cyano-1-phenyl-1H-pyrazol-5-yl]imidoformate (1448231-29-5)

Guidance literature:

With acetic anhydride; for 7h; Reflux;

DOI:10.3184/174751913X13570601346457

Reference yield:

phenylhydrazine (100-63-0) → ethyl N-[3-(1,1-biphenyl-4-yl)-4-cyano-1-phenyl-1H-pyrazol-5-yl]imidoformate (1448231-29-5)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine / 3.5 h

2: tetrachloromethane; triphenylphosphine / acetonitrile / 14 h / 20 °C / Reflux

3: sodium ethanolate / ethanol

4: acetic anhydride / 7 h / Reflux

With pyridine; tetrachloromethane; sodium ethanolate; acetic anhydride; triphenylphosphine; In ethanol; acetonitrile;

DOI:10.3184/174751913X13570601346457

Reference yield:

N'-phenyl-1,1-biphenyl-4-carbohydrazide (1448231-27-3) → ethyl N-[3-(1,1-biphenyl-4-yl)-4-cyano-1-phenyl-1H-pyrazol-5-yl]imidoformate (1448231-29-5)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrachloromethane; triphenylphosphine / acetonitrile / 14 h / 20 °C / Reflux

2: sodium ethanolate / ethanol

3: acetic anhydride / 7 h / Reflux

With tetrachloromethane; sodium ethanolate; acetic anhydride; triphenylphosphine; In ethanol; acetonitrile;

DOI:10.3184/174751913X13570601346457

upstream raw materials:

4-biphenyl-carboxylic acid chloride

phenylhydrazine

N'-phenyl-1,1-biphenyl-4-carbohydrazide

5-amino-3-(1,1-biphenyl-4-yl)-1-phenyl-1H-pyrazole-4-carbonitrile

Downstream raw materials:

3-(1,1-biphenyl-4-yl)-4-[2-(4-chlorobenzylidene)hydrazinyl]-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine

4-[2-(benzylidene)hydrazinyl]-3-(1,1-biphenyl-4-yl)-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine

3-(1,1-biphenyl-4-yl)-4-hydrazino-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine

3-(biphenyl-4-yl)-4-imino-1-phenyl-1,4-dihydro-5H-pyrazolo[3,4-d]pyrimidin-5-amine

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