5-Brom-2<(4-ethoxy-1,4-dioxobutyl)amino>benzoesaeureethylester

Base Information

• Chemical Name: 5-Brom-2<(4-ethoxy-1,4-dioxobutyl)amino>benzoesaeureethylester
• CAS No.: 137046-56-1
• Molecular Formula: C₁₅H₁₈BrNO₅
• Molecular Weight: 372.216
• Mol file: 137046-56-1.mol

Synonyms:5-Brom-2<(4-ethoxy-1,4-dioxobutyl)amino>benzoesaeureethylester

Chemical Property of 5-Brom-2<(4-ethoxy-1,4-dioxobutyl)amino>benzoesaeureethylester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 5-Brom-2<(4-ethoxy-1,4-dioxobutyl)amino>benzoesaeureethylester

There total 4 articles about 5-Brom-2<(4-ethoxy-1,4-dioxobutyl)amino>benzoesaeureethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.2%

diethyl ester of succinoylanthranilic acid (120572-43-2) → 5-Brom-2<(4-ethoxy-1,4-dioxobutyl)amino>benzoesaeureethylester (137046-56-1)

Guidance literature:

With bromine; sodium acetate; In acetic acid;

Reference yield: 79.0%

ethyl 3-(chloroformyl)propionate (14794-31-1,97900-84-0) + 2-amino-5-bromobenzoic acid,ethyl ester (63243-76-5) → 5-Brom-2<(4-ethoxy-1,4-dioxobutyl)amino>benzoesaeureethylester (137046-56-1)

Guidance literature:

With calcium carbonate; In toluene; for 1h; Reflux;

DOI:10.1016/j.bmcl.2009.07.153

Reference yield:

ethyl 3-(chloroformyl)propionate (14794-31-1,97900-84-0) → 5-Brom-2<(4-ethoxy-1,4-dioxobutyl)amino>benzoesaeureethylester (137046-56-1)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 20 °C

2: sodium acetate; bromine / acetic acid

With bromine; sodium acetate; triethylamine; In dichloromethane; acetic acid;

upstream raw materials:

diethyl ester of succinoylanthranilic acid

ethyl 3-(chloroformyl)propionate

2-amino-5-bromobenzoic acid,ethyl ester

2-ethoxycarbonylaniline

Downstream raw materials:

7-bromo-2,3,4,5-tetrahydro-1H-benzo[b]azepine