Technology Process of (R)-2-(3-(2-nitrophenyl)-5-oxo-5-phenylpentanoyl)pyridine 1-oxide
There total 3 articles about (R)-2-(3-(2-nitrophenyl)-5-oxo-5-phenylpentanoyl)pyridine 1-oxide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C14H10N2O4;
With
C43H41NO2; zinc trifluoromethanesulfonate;
In
benzene;
at 25 ℃;
for 0.25h;
Inert atmosphere;
1-styrenyloxytrimethylsilane;
In
benzene;
at 25 ℃;
for 2.5h;
enantioselective reaction;
DOI:10.1039/c3ob40445e
- Guidance literature:
-
2-(3-(2-nitrophenyl)acryloyl)pyridine N-oxide;
With
copper(II) bis(trifluoromethanesulfonate); (S,S)-2,2'-isopropylidenebis(4-phenyl-2-oxazoline);
In
dichloromethane;
at -50 - 20 ℃;
for 0.166667h;
Inert atmosphere;
1-styrenyloxytrimethylsilane;
In
dichloromethane;
at 50 ℃;
for 6h;
Overall yield = 91 %; enantioselective reaction;
Inert atmosphere;
DOI:10.1002/adsc.201200631
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 0.33 h / -78 - 0 °C / Inert atmosphere
1.2: 2 h / -78 - 20 °C / Inert atmosphere
2.1: copper(II) bis(trifluoromethanesulfonate); (S,S)-2,2'-isopropylidenebis(4-phenyl-2-oxazoline) / dichloromethane / 0.17 h / -50 - 20 °C / Inert atmosphere
2.2: 6 h / 50 °C / Inert atmosphere
With
n-butyllithium; copper(II) bis(trifluoromethanesulfonate); (S,S)-2,2'-isopropylidenebis(4-phenyl-2-oxazoline); diisopropylamine;
In
tetrahydrofuran; hexane; dichloromethane;
DOI:10.1002/adsc.201200631
