Technology Process of (S)-benzyl 3-nitro-2-phenylpropanoate
There total 3 articles about (S)-benzyl 3-nitro-2-phenylpropanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
[Ir(1,5-cyclooctadiene)((tBu)C7H10NOP(tBu))] tetrakis(3,5-bis(trifluoromethyl)phenyl)borate; hydrogen;
In
dichloromethane;
at 70 ℃;
for 96h;
under 38002.6 Torr;
enantioselective reaction;
Autoclave;
DOI:10.1021/acs.orglett.5b01758
- Guidance literature:
-
Multi-step reaction with 2 steps
1: triethylamine; methanesulfonyl chloride / dichloromethane / 20 °C / Inert atmosphere; Cooling with ice
2: hydrogen; [Ir(1,5-cyclooctadiene)((tBu)C7H10NOP(tBu))] tetrakis(3,5-bis(trifluoromethyl)phenyl)borate / dichloromethane / 96 h / 70 °C / 38002.6 Torr / Autoclave
With
[Ir(1,5-cyclooctadiene)((tBu)C7H10NOP(tBu))] tetrakis(3,5-bis(trifluoromethyl)phenyl)borate; hydrogen; methanesulfonyl chloride; triethylamine;
In
dichloromethane;
DOI:10.1021/acs.orglett.5b01758
- Guidance literature:
-
Multi-step reaction with 4 steps
1: dmap; dicyclohexyl-carbodiimide / toluene / 20 °C / Reflux
2: triethylamine / 20 °C / Schlenk technique; Inert atmosphere
3: triethylamine; methanesulfonyl chloride / dichloromethane / 20 °C / Inert atmosphere; Cooling with ice
4: hydrogen; [Ir(1,5-cyclooctadiene)((tBu)C7H10NOP(tBu))] tetrakis(3,5-bis(trifluoromethyl)phenyl)borate / dichloromethane / 96 h / 70 °C / 38002.6 Torr / Autoclave
With
dmap; [Ir(1,5-cyclooctadiene)((tBu)C7H10NOP(tBu))] tetrakis(3,5-bis(trifluoromethyl)phenyl)borate; hydrogen; methanesulfonyl chloride; triethylamine; dicyclohexyl-carbodiimide;
In
dichloromethane; toluene;
2: |Henry Nitro Aldol Condensation;
DOI:10.1021/acs.orglett.5b01758
