1070237-53-4Relevant academic research and scientific papers
Organocatalytic Enantioselective Michael Reaction of Malononitrile with β,β-Disubstituted Nitroalkenes
Chen, Shengwei,Lou, Qinxin,Ding, Yuyang,Zhang, Shasha,Hu, Wenhui,Zhao, Junling
, p. 2437 - 2441 (2015/08/18)
We have developed and optimized an enantioselective Michael reaction of malononitrile with β,β-disubstituted nitroalkenes. This reaction was catalyzed by a cinchona alkaloid derived thiourea catalyst, producing products of high yields (up to 98 %) and ste
First Iridium-Catalyzed Highly Enantioselective Hydrogenation of β-Nitroacrylates
Li, Shengkun,Xiao, Taifeng,Li, Dangdang,Zhang, Xumu
, p. 3782 - 3785 (2015/08/18)
The first highly chemo- and enantioselective hydrogenation of β-nitroacrylates was accomplished with an iridium catalyst (Ir-4) with yields and enantioselectivities of up to 96% and 98% ee, respectively. The resulting α-chiral β-nitro propionates are attractive building blocks for the synthesis of chiral β2-amino acids, which are the core scaffolds of bioactive natural products, pharmaceuticals, and β-peptides.
Organocatalytic asymmetric transferhydrogenation of β-nitroacrylates: Accessing β2-amino acids
Martin, Nolwenn J. A.,Cheng, Xu,List, Benjamin
supporting information; experimental part, p. 13862 - 13863 (2009/02/06)
We describe a highly efficient and enantioselective Hantzsch ester mediated conjugate reduction of β-nitroacrylates that is catalyzed by a Jacobsen thiourea catalyst as a key step in a new route to optically active β2-amino acids. Copyright
