1070236-97-3Relevant academic research and scientific papers
Copper-Catalyzed Cross-Dehydrogenative Coupling of α-Hydroxy Esters with Nitromethane
Xiao, Lili,Jiang, Jin
supporting information, p. 1861 - 1864 (2021/08/06)
An efficient copper-catalyzed tandem oxidation/nitroaldol reaction of hydroxyl compounds with nucleophiles is developed. In this work, -nitro-hydroxy esters were prepared via cross-dehydrogenative coupling reaction using -hydroxy esters as hydroxy compounds and nitromethane as a nucleophile. The reaction is believed to undergo an oxidation of the hydroxyl group and then an addition of the generated carbonyl group. It is an example of CDC reactions related to hydroxyl compounds via carbonyl intermediates.
Organocatalytic Enantioselective Michael Reaction of Malononitrile with β,β-Disubstituted Nitroalkenes
Chen, Shengwei,Lou, Qinxin,Ding, Yuyang,Zhang, Shasha,Hu, Wenhui,Zhao, Junling
supporting information, p. 2437 - 2441 (2015/08/18)
We have developed and optimized an enantioselective Michael reaction of malononitrile with β,β-disubstituted nitroalkenes. This reaction was catalyzed by a cinchona alkaloid derived thiourea catalyst, producing products of high yields (up to 98 %) and ste
First Iridium-Catalyzed Highly Enantioselective Hydrogenation of β-Nitroacrylates
Li, Shengkun,Xiao, Taifeng,Li, Dangdang,Zhang, Xumu
, p. 3782 - 3785 (2015/08/18)
The first highly chemo- and enantioselective hydrogenation of β-nitroacrylates was accomplished with an iridium catalyst (Ir-4) with yields and enantioselectivities of up to 96% and 98% ee, respectively. The resulting α-chiral β-nitro propionates are attractive building blocks for the synthesis of chiral β2-amino acids, which are the core scaffolds of bioactive natural products, pharmaceuticals, and β-peptides.
Organocatalytic asymmetric transferhydrogenation of β-nitroacrylates: Accessing β2-amino acids
Martin, Nolwenn J. A.,Cheng, Xu,List, Benjamin
supporting information; experimental part, p. 13862 - 13863 (2009/02/06)
We describe a highly efficient and enantioselective Hantzsch ester mediated conjugate reduction of β-nitroacrylates that is catalyzed by a Jacobsen thiourea catalyst as a key step in a new route to optically active β2-amino acids. Copyright
