tert-butyl 2-(6-(4-(diethoxyphosphoryl)phenyl)pyridin-3-yl)propan-2-ylcarbamate

Base Information

Chemical Name:tert-butyl 2-(6-(4-(diethoxyphosphoryl)phenyl)pyridin-3-yl)propan-2-ylcarbamate
CAS No.:1436433-27-0
Molecular Formula:C₂₃H₃₃N₂O₅P
Molecular Weight:448.499
Hs Code.:

Synonyms:tert-butyl 2-(6-(4-(diethoxyphosphoryl)phenyl)pyridin-3-yl)propan-2-ylcarbamate

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Chemical Property of tert-butyl 2-(6-(4-(diethoxyphosphoryl)phenyl)pyridin-3-yl)propan-2-ylcarbamate

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Technology Process of tert-butyl 2-(6-(4-(diethoxyphosphoryl)phenyl)pyridin-3-yl)propan-2-ylcarbamate

There total 9 articles about tert-butyl 2-(6-(4-(diethoxyphosphoryl)phenyl)pyridin-3-yl)propan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.4%

: 598-02-7
Diethyl phosphate

: 1428527-64-3
tert-butyl 2-(6-(4-bromophenyl)pyridin-3-yl)propan-2-ylcarbamate

: 1436433-27-0
tert-butyl 2-(6-(4-(diethoxyphosphoryl)phenyl)pyridin-3-yl)propan-2-ylcarbamate

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine; In toluene; for 8h; Inert atmosphere; Reflux;

Reference yield: 92.4%

: 1428527-64-3
tert-butyl 2-(6-(4-bromophenyl)pyridin-3-yl)propan-2-ylcarbamate

: 762-04-9
phosphonic acid diethyl ester

: 1436433-27-0
tert-butyl 2-(6-(4-(diethoxyphosphoryl)phenyl)pyridin-3-yl)propan-2-ylcarbamate

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine; In toluene; for 8h; Inert atmosphere; Reflux;

Reference yield:

: 73781-91-6
6-Chloronicotinic acid methyl ester

: 1436433-27-0
tert-butyl 2-(6-(4-(diethoxyphosphoryl)phenyl)pyridin-3-yl)propan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 7 steps

1: methylmagnesium chloride / tetrahydrofuran / 0.5 h / 0 - 20 °C

2: sulfuric acid / acetonitrile / 24 h / 0 - 20 °C

3: hydrogenchloride; sodium iodide / acetonitrile / 60 h / Reflux

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane / 3 h / 95 °C

5: hydrogenchloride / water / 60 h / Reflux

6: triethylamine / dichloromethane / 20 °C

7: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / toluene / 8 h / Inert atmosphere; Reflux

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; methylmagnesium chloride; sodium carbonate; triethylamine; sodium iodide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; toluene; acetonitrile;