tert-butyl 5-[(1-(4-methoxybenzyl)-1H-1,2,3-triazol-4-yl)methyl]-1,2,5-thiadiazolidine-2-carboxylate 1,1-dioxide

Base Information

• Chemical Name: tert-butyl 5-[(1-(4-methoxybenzyl)-1H-1,2,3-triazol-4-yl)methyl]-1,2,5-thiadiazolidine-2-carboxylate 1,1-dioxide
• CAS No.: 1341126-82-6
• Molecular Formula: C₁₈H₂₅N₅O₅S
• Molecular Weight: 423.493
• Mol file: 1341126-82-6.mol

Synonyms:tert-butyl 5-[(1-(4-methoxybenzyl)-1H-1,2,3-triazol-4-yl)methyl]-1,2,5-thiadiazolidine-2-carboxylate 1,1-dioxide

Chemical Property of tert-butyl 5-[(1-(4-methoxybenzyl)-1H-1,2,3-triazol-4-yl)methyl]-1,2,5-thiadiazolidine-2-carboxylate 1,1-dioxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 5-[(1-(4-methoxybenzyl)-1H-1,2,3-triazol-4-yl)methyl]-1,2,5-thiadiazolidine-2-carboxylate 1,1-dioxide

There total 4 articles about tert-butyl 5-[(1-(4-methoxybenzyl)-1H-1,2,3-triazol-4-yl)methyl]-1,2,5-thiadiazolidine-2-carboxylate 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

tert-butyl 5-(prop-2-yn-1-yl)-1,2,5-thiadiazolidine-2-carboxylate 1,1-dioxide (1341126-80-4) + 1-(azidomethyl)-4-methoxybenzene (70978-37-9) → tert-butyl 5-[(1-(4-methoxybenzyl)-1H-1,2,3-triazol-4-yl)methyl]-1,2,5-thiadiazolidine-2-carboxylate 1,1-dioxide (1341126-82-6)

Guidance literature:

With sodium ascorbate; copper(II) sulfate; In water; tert-butyl alcohol; at 20 ℃;

DOI:10.1016/j.bmc.2011.08.054

Reference yield:

N-tert-butyloxycarbonylsulfamoyl chloride (147000-89-3) → tert-butyl 5-[(1-(4-methoxybenzyl)-1H-1,2,3-triazol-4-yl)methyl]-1,2,5-thiadiazolidine-2-carboxylate 1,1-dioxide (1341126-82-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 0 - 20 °C

2.1: potassium carbonate / dimethyl sulfoxide / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h

3.2: 20 °C

4.1: sodium ascorbate; copper(II) sulfate / water; tert-butyl alcohol / 20 °C

With sodium ascorbate; sodium hydride; potassium carbonate; copper(II) sulfate; triethylamine; In dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; tert-butyl alcohol;

DOI:10.1016/j.bmc.2011.08.054

Reference yield:

tert-butyl 1,2,5-thiadiazolidine-2-carboxylate1,1-dioxide (263719-76-2) → tert-butyl 5-[(1-(4-methoxybenzyl)-1H-1,2,3-triazol-4-yl)methyl]-1,2,5-thiadiazolidine-2-carboxylate 1,1-dioxide (1341126-82-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h

1.2: 20 °C

2.1: sodium ascorbate; copper(II) sulfate / water; tert-butyl alcohol / 20 °C

With sodium ascorbate; sodium hydride; copper(II) sulfate; In water; N,N-dimethyl-formamide; tert-butyl alcohol;

DOI:10.1016/j.bmc.2011.08.054

upstream raw materials:

tert-butyl 5-(prop-2-yn-1-yl)-1,2,5-thiadiazolidine-2-carboxylate 1,1-dioxide

1-(azidomethyl)-4-methoxybenzene

N-tert-butyloxycarbonylsulfamoyl chloride

N¹-BOC,N³-(2-chloroethyl) sulfamide

Downstream raw materials:

2-{[1-(4-methoxybenzyl)-1H-1,2,3-triazol-4-yl]methyl}-1,2,5-thiadiazolidine 1,1-dioxide