(2R)-tert-butyl 2-(2-bromo-5-fluorophenyl)-4-hydroxypyrrolidine-1-carboxylate

Base Information

Chemical Name:(2R)-tert-butyl 2-(2-bromo-5-fluorophenyl)-4-hydroxypyrrolidine-1-carboxylate
CAS No.:1364890-49-2
Molecular Formula:C₁₅H₁₉BrFNO₃
Molecular Weight:360.223
Hs Code.:

Synonyms:(2R)-tert-butyl 2-(2-bromo-5-fluorophenyl)-4-hydroxypyrrolidine-1-carboxylate

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Chemical Property of (2R)-tert-butyl 2-(2-bromo-5-fluorophenyl)-4-hydroxypyrrolidine-1-carboxylate

Chemical Property:

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Technology Process of (2R)-tert-butyl 2-(2-bromo-5-fluorophenyl)-4-hydroxypyrrolidine-1-carboxylate

There total 6 articles about (2R)-tert-butyl 2-(2-bromo-5-fluorophenyl)-4-hydroxypyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1364890-48-1
C₁₇H₂₁BrFNO₄

: 1364890-49-2
(2R)-tert-butyl 2-(2-bromo-5-fluorophenyl)-4-hydroxypyrrolidine-1-carboxylate

Guidance literature:: With methanol; sodium hydroxide; at 0 - 20 ℃;

Reference yield:

: 94569-84-3
2-bromo-5-fluorobenzaldehyde

: 1364890-49-2
(2R)-tert-butyl 2-(2-bromo-5-fluorophenyl)-4-hydroxypyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: titanium(IV) tetraethanolate / tetrahydrofuran / 16 h / 20 °C

2.1: dichloromethane; tetrahydrofuran / 5 h / -78 °C

3.1: hydrogenchloride / methanol / 0.75 h / 20 °C

3.2: 0 °C

4.1: dichloromethane / 2 h / 0 °C

5.1: iodine / water; tetrahydrofuran / 6 h

6.1: sodium hydroxide / water; tetrahydrofuran / 3 h / pH 9

7.1: sodium hydroxide; methanol / 0 - 20 °C

With hydrogenchloride; methanol; titanium(IV) tetraethanolate; iodine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water;

Reference yield:

: 1364890-43-6
(S,E)-N-(2-bromo-5-fluorobenzylidene)-tert-butanesulfinamide

: 1364890-49-2
(2R)-tert-butyl 2-(2-bromo-5-fluorophenyl)-4-hydroxypyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: dichloromethane; tetrahydrofuran / 5 h / -78 °C

2.1: hydrogenchloride / methanol / 0.75 h / 20 °C

2.2: 0 °C

3.1: dichloromethane / 2 h / 0 °C

4.1: iodine / water; tetrahydrofuran / 6 h

5.1: sodium hydroxide / water; tetrahydrofuran / 3 h / pH 9

6.1: sodium hydroxide; methanol / 0 - 20 °C

With hydrogenchloride; methanol; iodine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water;