2-[{4-[(hydroxyamino)carbonyl]benzyl}(2-naphthylmethyl)amino]ethyl 2-{[(4-methoxyphenyl)(diphenyl)methyl]sulfanyl}ethyl carbonate

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Chemical Name:2-[{4-[(hydroxyamino)carbonyl]benzyl}(2-naphthylmethyl)amino]ethyl 2-{[(4-methoxyphenyl)(diphenyl)methyl]sulfanyl}ethyl carbonate
CAS No.:1372720-46-1
Molecular Formula:C₄₄H₄₂N₂O₆S
Molecular Weight:726.893
Hs Code.:

Synonyms:2-[{4-[(hydroxyamino)carbonyl]benzyl}(2-naphthylmethyl)amino]ethyl 2-{[(4-methoxyphenyl)(diphenyl)methyl]sulfanyl}ethyl carbonate

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Chemical Property of 2-[{4-[(hydroxyamino)carbonyl]benzyl}(2-naphthylmethyl)amino]ethyl 2-{[(4-methoxyphenyl)(diphenyl)methyl]sulfanyl}ethyl carbonate

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Technology Process of 2-[{4-[(hydroxyamino)carbonyl]benzyl}(2-naphthylmethyl)amino]ethyl 2-{[(4-methoxyphenyl)(diphenyl)methyl]sulfanyl}ethyl carbonate

There total 3 articles about 2-[{4-[(hydroxyamino)carbonyl]benzyl}(2-naphthylmethyl)amino]ethyl 2-{[(4-methoxyphenyl)(diphenyl)methyl]sulfanyl}ethyl carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1372720-45-0
2-{[(4-methoxyphenyl)(diphenyl)methyl]sulfanyl}ethyl 2-[(2-naphthylmethyl)(4-{[(tetrahydro-2H-pyran-2-yloxy)amino]carbonyl}benzyl)amino]ethyl carbonate

: 1372720-46-1
2-[{4-[(hydroxyamino)carbonyl]benzyl}(2-naphthylmethyl)amino]ethyl 2-{[(4-methoxyphenyl)(diphenyl)methyl]sulfanyl}ethyl carbonate

Guidance literature:: With acetic acid; In tetrahydrofuran; water; at 60 ℃; for 6h;
DOI:10.1248/cpb.59.1386

Reference yield:

: 14470-28-1
mono-4-methoxytrityl chloride

: 1372720-46-1
2-[{4-[(hydroxyamino)carbonyl]benzyl}(2-naphthylmethyl)amino]ethyl 2-{[(4-methoxyphenyl)(diphenyl)methyl]sulfanyl}ethyl carbonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / N,N-dimethyl-formamide / 3 h / 20 °C

2.1: dmap; bis(trichloromethyl) carbonate / dichloromethane / 0.25 h / 20 °C

2.2: 7 h / 20 °C

3.1: acetic acid / tetrahydrofuran; water / 6 h / 60 °C

With dmap; bis(trichloromethyl) carbonate; acetic acid; triethylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1248/cpb.59.1386

Reference yield:

: 1198587-13-1
4-{[(2-hydroxyethyl)(2-naphthylmethyl)amino]methyl}-N-(tetrahydro-2H-pyran-2-yloxy)benzamide

: 908082-76-8
2-{[(4-methoxyphenyl)(diphenyl)methyl]sulfanyl}ethanol

: 1372720-46-1
2-[{4-[(hydroxyamino)carbonyl]benzyl}(2-naphthylmethyl)amino]ethyl 2-{[(4-methoxyphenyl)(diphenyl)methyl]sulfanyl}ethyl carbonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap; bis(trichloromethyl) carbonate / dichloromethane / 0.25 h / 20 °C

1.2: 7 h / 20 °C

2.1: acetic acid / tetrahydrofuran; water / 6 h / 60 °C

With dmap; bis(trichloromethyl) carbonate; acetic acid; In tetrahydrofuran; dichloromethane; water;
DOI:10.1248/cpb.59.1386