4-{[(2-hydroxyethyl)(2-naphthylmethyl)amino]methyl}-N-(tetrahydro-2H-pyran-2-yloxy)benzamide

Base Information

• Chemical Name: 4-{[(2-hydroxyethyl)(2-naphthylmethyl)amino]methyl}-N-(tetrahydro-2H-pyran-2-yloxy)benzamide
• CAS No.: 1198587-13-1
• Molecular Formula: C₂₆H₃₀N₂O₄
• Molecular Weight: 434.535

Synonyms:4-{[(2-hydroxyethyl)(2-naphthylmethyl)amino]methyl}-N-(tetrahydro-2H-pyran-2-yloxy)benzamide

Chemical Property of 4-{[(2-hydroxyethyl)(2-naphthylmethyl)amino]methyl}-N-(tetrahydro-2H-pyran-2-yloxy)benzamide

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Technology Process of 4-{[(2-hydroxyethyl)(2-naphthylmethyl)amino]methyl}-N-(tetrahydro-2H-pyran-2-yloxy)benzamide

There total 1 articles about 4-{[(2-hydroxyethyl)(2-naphthylmethyl)amino]methyl}-N-(tetrahydro-2H-pyran-2-yloxy)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.5%

4-{[(2-naphthylmethyl)amino]methyl}-N-(tetrahydro-2H-pyran-2-yloxy)benzamide (1198587-21-1) + 2-bromoethanol (540-51-2) → 4-{[(2-hydroxyethyl)(2-naphthylmethyl)amino]methyl}-N-(tetrahydro-2H-pyran-2-yloxy)benzamide (1198587-13-1)

Guidance literature:

With triethylamine; In acetonitrile; at 60 ℃; for 6h;

DOI:10.1016/j.ejmech.2009.06.036

Reference yield: 65.8%

4-{[(2-hydroxyethyl)(2-naphthylmethyl)amino]methyl}-N-(tetrahydro-2H-pyran-2-yloxy)benzamide (1198587-13-1) + cholesteryl hemisuccinate (1510-21-0) → 1-cholest-5-en-3-yl 4-{2-[(2-naphthylmethyl)(4-{[(tetrahydro-2H-pyran-2-yloxy)amino]carbonyl}benzyl)amino]ethyl} succinate (1198587-15-3)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1016/j.ejmech.2009.06.036

Reference yield: 60.2%

lauric acid (143-07-7) + 4-{[(2-hydroxyethyl)(2-naphthylmethyl)amino]methyl}-N-(tetrahydro-2H-pyran-2-yloxy)benzamide (1198587-13-1) → 2-[(2-naphthylmethyl)(4-{[(tetrahydro-2H-pyran-2-yloxy)amino]carbonyl}benzyl)amino] ethyl laurate (1198587-14-2)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 5h;

DOI:10.1016/j.ejmech.2009.06.036

upstream raw materials:

4-{[(2-naphthylmethyl)amino]methyl}-N-(tetrahydro-2H-pyran-2-yloxy)benzamide

2-bromoethanol

Downstream raw materials:

2-[(2-naphthylmethyl)(4-{[(tetrahydro-2H-pyran-2-yloxy)amino]carbonyl}benzyl)amino] ethyl laurate

1-cholest-5-en-3-yl 4-{2-[(2-naphthylmethyl)(4-{[(tetrahydro-2H-pyran-2-yloxy)amino]carbonyl}benzyl)amino]ethyl} succinate

2-{[(4-methoxyphenyl)(diphenyl)methyl]sulfanyl}ethyl 2-[(2-naphthylmethyl)(4-{[(tetrahydro-2H-pyran-2-yloxy)amino]carbonyl}benzyl)amino]ethyl carbonate

2-[{4-[(hydroxyamino)carbonyl]benzyl}(2-naphthylmethyl)amino]ethyl 2-{[(4-methoxyphenyl)(diphenyl)methyl]sulfanyl}ethyl carbonate

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