(1R,9bR)-7,8-Dimethoxy-5,5-dioxo-1,9b-diphenyl-3,4,5,9b-tetrahydro-1H-5λ⁶-thia-2a-aza-benzo[a]cyclobuta[c]cyclohepten-2-one

Base Information

• Chemical Name: (1R,9bR)-7,8-Dimethoxy-5,5-dioxo-1,9b-diphenyl-3,4,5,9b-tetrahydro-1H-5λ⁶-thia-2a-aza-benzo[a]cyclobuta[c]cyclohepten-2-one
• CAS No.: 111708-88-4
• Molecular Formula: C₂₅H₂₃NO₅S
• Molecular Weight: 449.527

Synonyms:(1R,9bR)-7,8-Dimethoxy-5,5-dioxo-1,9b-diphenyl-3,4,5,9b-tetrahydro-1H-5λ⁶-thia-2a-aza-benzo[a]cyclobuta[c]cyclohepten-2-one

Chemical Property of (1R,9bR)-7,8-Dimethoxy-5,5-dioxo-1,9b-diphenyl-3,4,5,9b-tetrahydro-1H-5λ⁶-thia-2a-aza-benzo[a]cyclobuta[c]cyclohepten-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (1R,9bR)-7,8-Dimethoxy-5,5-dioxo-1,9b-diphenyl-3,4,5,9b-tetrahydro-1H-5λ⁶-thia-2a-aza-benzo[a]cyclobuta[c]cyclohepten-2-one

There total 7 articles about (1R,9bR)-7,8-Dimethoxy-5,5-dioxo-1,9b-diphenyl-3,4,5,9b-tetrahydro-1H-5λ⁶-thia-2a-aza-benzo[a]cyclobuta[c]cyclohepten-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.3%

(1R*,9bS*)-8,9-dimethoxy-1,10b-diphenyl-1,4,5,10b-tetrahydro-2H-azeto[2,1-d][1,4]benzothiazepin-2-one (111708-78-2) → (1R,9bR)-7,8-Dimethoxy-5,5-dioxo-1,9b-diphenyl-3,4,5,9b-tetrahydro-1H-5λ6-thia-2a-aza-benzo[a]cyclobuta[c]cyclohepten-2-one (111708-88-4)

Guidance literature:

With peracetic acid; In acetic acid;

DOI:10.1139/v87-027

Reference yield: 40.4%

2,3-dihydro-7,8-dimethoxy-5-phenyl-1,4-benzothiazepine 1,1-dioxide (111708-75-9) + phenylacetyl chloride (103-80-0) → (1R,9bR)-7,8-Dimethoxy-5,5-dioxo-1,9b-diphenyl-3,4,5,9b-tetrahydro-1H-5λ6-thia-2a-aza-benzo[a]cyclobuta[c]cyclohepten-2-one (111708-88-4)

Guidance literature:

With triethylamine; In benzene; for 1h; Heating;

DOI:10.1139/v87-027

Reference yield:

2-((3,4-dimethoxyphenyl)thio)ethan-1-amine hydrochloride (111708-66-8) → (1R,9bR)-7,8-Dimethoxy-5,5-dioxo-1,9b-diphenyl-3,4,5,9b-tetrahydro-1H-5λ6-thia-2a-aza-benzo[a]cyclobuta[c]cyclohepten-2-one (111708-88-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 90 percent / pyridine / 0.5 h

2: 36.7 percent / POCl₃ / 3 h / Heating

3: 54.5 percent / KMnO₄ / dioxane; H₂O; acetic acid / 1 h

4: 40.4 percent / triethylamine / benzene / 1 h / Heating

With pyridine; potassium permanganate; triethylamine; trichlorophosphate; In 1,4-dioxane; water; acetic acid; benzene;

DOI:10.1139/v87-027

upstream raw materials:

(1R*,9bS*)-8,9-dimethoxy-1,10b-diphenyl-1,4,5,10b-tetrahydro-2H-azeto[2,1-d][1,4]benzothiazepin-2-one

2,3-dihydro-7,8-dimethoxy-5-phenyl-1,4-benzothiazepine 1,1-dioxide

phenylacetyl chloride

2-((3,4-dimethoxyphenyl)thio)ethan-1-amine hydrochloride

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