(2S,5R)-5-(2-Methanesulfonyloxy-ethyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester

Base Information

Chemical Name:(2S,5R)-5-(2-Methanesulfonyloxy-ethyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester
CAS No.:182137-68-4
Molecular Formula:C₂₀H₂₉NO₇S
Molecular Weight:427.519
Hs Code.:

Synonyms:(2S,5R)-5-(2-Methanesulfonyloxy-ethyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester

Suppliers and Price of (2S,5R)-5-(2-Methanesulfonyloxy-ethyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,5R)-5-(2-Methanesulfonyloxy-ethyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,5R)-5-(2-Methanesulfonyloxy-ethyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester

There total 7 articles about (2S,5R)-5-(2-Methanesulfonyloxy-ethyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 124-63-0
methanesulfonyl chloride

: 178813-40-6
(2S,5R)-5-(2-Hydroxy-ethyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester

: 182137-68-4
(2S,5R)-5-(2-Methanesulfonyloxy-ethyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester

Guidance literature:: With triethylamine; In dichloromethane; 1.) 0 deg C, 5 min, 2.) room temperature, 5 min;
DOI:10.1021/jo960759m

Reference yield:

: 90741-31-4
(S)-N-benzyl-5-thioxoproline tert-butyl ester

: 182137-68-4
(2S,5R)-5-(2-Methanesulfonyloxy-ethyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 2.) Ph₃P, NMP / 1.) CH₃CN, 42 h, 2.) CH₂Cl₂, -5 deg C, 30 h.

2: 98 percent / H₂ / Pt/C / ethyl acetate / 16 h / 3102.9 Torr

3: 94 percent / LiBH₄ / diethyl ether / 4.5 h

4: H₂ / Pd/C / methanol / 12 h / 3102.9 Torr

5: K₂CO₃ / ethyl acetate; H₂O / 1.5 h

6: 100 percent / Et₃N / CH₂Cl₂ / 1.) 0 deg C, 5 min, 2.) room temperature, 5 min

With 1-methyl-pyrrolidin-2-one; lithium borohydride; hydrogen; potassium carbonate; triethylamine; triphenylphosphine; palladium on activated charcoal; platinum on activated charcoal; In methanol; diethyl ether; dichloromethane; water; ethyl acetate;
DOI:10.1021/jo960759m

Reference yield:

: 90741-33-6
(2S)-1-benzyl-(E)-5-<(methoxycarbonyl)methylidene>proline tert-butyl ester

: 182137-68-4
(2S,5R)-5-(2-Methanesulfonyloxy-ethyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / H₂ / Pt/C / ethyl acetate / 16 h / 3102.9 Torr

2: 94 percent / LiBH₄ / diethyl ether / 4.5 h

3: H₂ / Pd/C / methanol / 12 h / 3102.9 Torr

4: K₂CO₃ / ethyl acetate; H₂O / 1.5 h

5: 100 percent / Et₃N / CH₂Cl₂ / 1.) 0 deg C, 5 min, 2.) room temperature, 5 min

With lithium borohydride; hydrogen; potassium carbonate; triethylamine; palladium on activated charcoal; platinum on activated charcoal; In methanol; diethyl ether; dichloromethane; water; ethyl acetate;
DOI:10.1021/jo960759m