6-(4-{[({6-[(bis-tert-butoxycarbonyl)amino]pyridin-3-yl}methyl)carbamoyl]amino}-3-fluorophenyl)-2-(ethylamino)nicotinic acid

Base Information

Chemical Name:6-(4-{[({6-[(bis-tert-butoxycarbonyl)amino]pyridin-3-yl}methyl)carbamoyl]amino}-3-fluorophenyl)-2-(ethylamino)nicotinic acid
CAS No.:1246494-92-7
Molecular Formula:C₃₁H₃₇FN₆O₇
Molecular Weight:624.669
Hs Code.:

Synonyms:6-(4-{[({6-[(bis-tert-butoxycarbonyl)amino]pyridin-3-yl}methyl)carbamoyl]amino}-3-fluorophenyl)-2-(ethylamino)nicotinic acid

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Chemical Property of 6-(4-{[({6-[(bis-tert-butoxycarbonyl)amino]pyridin-3-yl}methyl)carbamoyl]amino}-3-fluorophenyl)-2-(ethylamino)nicotinic acid

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Technology Process of 6-(4-{[({6-[(bis-tert-butoxycarbonyl)amino]pyridin-3-yl}methyl)carbamoyl]amino}-3-fluorophenyl)-2-(ethylamino)nicotinic acid

There total 4 articles about 6-(4-{[({6-[(bis-tert-butoxycarbonyl)amino]pyridin-3-yl}methyl)carbamoyl]amino}-3-fluorophenyl)-2-(ethylamino)nicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1092523-21-1
6-chloro-2-(ethylamino)pyridine-3-carboxylic acid

: 1246494-90-5
di(tert-butyl) {5-[({[2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]carbamoyl}amino)methyl]pyridin-2-yl}imidodicarbonate

: C₂₆H₂₉FN₆O₅

: 1246494-92-7
6-(4-{[({6-[(bis-tert-butoxycarbonyl)amino]pyridin-3-yl}methyl)carbamoyl]amino}-3-fluorophenyl)-2-(ethylamino)nicotinic acid

Guidance literature:: With sodium hydrogencarbonate; In 1,2-dimethoxyethane; ethanol; for 18h; Inert atmosphere; Reflux;

Reference yield:

: 38496-18-3
2,6-dichloropyridine-3-carboxylic acid

: C₂₆H₂₉FN₆O₅

: 1246494-92-7
6-(4-{[({6-[(bis-tert-butoxycarbonyl)amino]pyridin-3-yl}methyl)carbamoyl]amino}-3-fluorophenyl)-2-(ethylamino)nicotinic acid

Guidance literature:: Multi-step reaction with 2 steps

1: water / 120 h / 20 °C

2: sodium hydrogencarbonate / 1,2-dimethoxyethane; ethanol / 18 h / Inert atmosphere; Reflux

With sodium hydrogencarbonate; In 1,2-dimethoxyethane; ethanol; water;

Reference yield:

: 819058-34-9
2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

: C₂₆H₂₉FN₆O₅

: 1246494-92-7
6-(4-{[({6-[(bis-tert-butoxycarbonyl)amino]pyridin-3-yl}methyl)carbamoyl]amino}-3-fluorophenyl)-2-(ethylamino)nicotinic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap / tetrahydrofuran / 18 h / 20 °C

1.2: 5 h / 20 °C

2.1: sodium hydrogencarbonate / 1,2-dimethoxyethane; ethanol / 18 h / Inert atmosphere; Reflux

With dmap; sodium hydrogencarbonate; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol;