phenyl 4-(benzyloxy)-7-methoxy-6-methyl-2-tert-pentylisoindoline-5-carboxylate

Base Information

Chemical Name:phenyl 4-(benzyloxy)-7-methoxy-6-methyl-2-tert-pentylisoindoline-5-carboxylate
CAS No.:1335556-22-3
Molecular Formula:C₂₉H₃₃NO₄
Molecular Weight:459.585
Hs Code.:

Synonyms:phenyl 4-(benzyloxy)-7-methoxy-6-methyl-2-tert-pentylisoindoline-5-carboxylate

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Chemical Property of phenyl 4-(benzyloxy)-7-methoxy-6-methyl-2-tert-pentylisoindoline-5-carboxylate

Chemical Property:

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Technology Process of phenyl 4-(benzyloxy)-7-methoxy-6-methyl-2-tert-pentylisoindoline-5-carboxylate

There total 14 articles about phenyl 4-(benzyloxy)-7-methoxy-6-methyl-2-tert-pentylisoindoline-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 594-39-8
2-methyl-2-butylamine

: 1335557-47-5
C₂₄H₂₂Cl₂O₄

: 1335556-22-3
phenyl 4-(benzyloxy)-7-methoxy-6-methyl-2-tert-pentylisoindoline-5-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1,2-dimethoxyethane; at 110 ℃; Sealed;

Reference yield:

: 877149-05-8
4-bromo-2-methoxy-6-methyl-benzonitrile

: 1335556-22-3
phenyl 4-(benzyloxy)-7-methoxy-6-methyl-2-tert-pentylisoindoline-5-carboxylate

Guidance literature:: Multi-step reaction with 13 steps

1.1: diisobutylaluminium hydride / toluene; tetrahydrofuran / -78 - 20 °C

1.2: 0 - 20 °C

2.1: 2-methyl-but-2-ene; water; sodium chlorite; sodium dihydrogenphosphate / tert-butyl alcohol / 0.5 h / 20 °C

2.2: pH 1

3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.5 h / 20 °C

4.1: dmap; triethylamine / dichloromethane / 1 h / 20 °C

5.1: boron tribromide / dichloromethane / 0.58 h / -78 - 0 °C

5.2: 0.33 h / 20 °C

6.1: [bis(acetoxy)iodo]benzene / 1,4-dioxane / 0 - 20 °C

6.2: 0.33 h / 20 °C

7.1: dmap / dichloromethane / 0.33 h / 20 °C

8.1: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1 h / 0 °C

8.2: 0.5 h / 0 - 20 °C

9.1: trifluoroacetic acid / dichloromethane / 0 - 10 °C

9.2: 10 - 20 °C

10.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 0 °C

10.2: 0.5 h / 0 °C

11.1: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

11.2: 0.5 h / 0 °C

12.1: thionyl chloride; tetrabutyl-ammonium chloride / 1,2-dichloro-ethane / 1.5 h / 80 °C / Sealed

13.1: N-ethyl-N,N-diisopropylamine / 1,2-dimethoxyethane / 110 °C / Sealed

With dmap; sodium chlorite; sodium dihydrogenphosphate; thionyl chloride; 2-methyl-but-2-ene; oxalyl dichloride; [bis(acetoxy)iodo]benzene; tetrabutyl-ammonium chloride; water; isopropylmagnesium chloride; boron tribromide; diisobutylaluminium hydride; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium chloride; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;

Reference yield:

: 348169-39-1
4-bromo-2-methoxy-6-methyl-phenylamine

: 1335556-22-3
phenyl 4-(benzyloxy)-7-methoxy-6-methyl-2-tert-pentylisoindoline-5-carboxylate

Guidance literature:: Multi-step reaction with 14 steps

1.1: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 °C

1.3: 4 h / 0 - 50 °C

2.1: diisobutylaluminium hydride / toluene; tetrahydrofuran / -78 - 20 °C

2.2: 0 - 20 °C

3.1: 2-methyl-but-2-ene; water; sodium chlorite; sodium dihydrogenphosphate / tert-butyl alcohol / 0.5 h / 20 °C

3.2: pH 1

4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.5 h / 20 °C

5.1: dmap; triethylamine / dichloromethane / 1 h / 20 °C

6.1: boron tribromide / dichloromethane / 0.58 h / -78 - 0 °C

6.2: 0.33 h / 20 °C

7.1: [bis(acetoxy)iodo]benzene / 1,4-dioxane / 0 - 20 °C

7.2: 0.33 h / 20 °C

8.1: dmap / dichloromethane / 0.33 h / 20 °C

9.1: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1 h / 0 °C

9.2: 0.5 h / 0 - 20 °C

10.1: trifluoroacetic acid / dichloromethane / 0 - 10 °C

10.2: 10 - 20 °C

11.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 0 °C

11.2: 0.5 h / 0 °C

12.1: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

12.2: 0.5 h / 0 °C

13.1: thionyl chloride; tetrabutyl-ammonium chloride / 1,2-dichloro-ethane / 1.5 h / 80 °C / Sealed

14.1: N-ethyl-N,N-diisopropylamine / 1,2-dimethoxyethane / 110 °C / Sealed

With hydrogenchloride; dmap; sodium chlorite; sodium dihydrogenphosphate; thionyl chloride; 2-methyl-but-2-ene; oxalyl dichloride; [bis(acetoxy)iodo]benzene; tetrabutyl-ammonium chloride; water; isopropylmagnesium chloride; boron tribromide; diisobutylaluminium hydride; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium chloride; sodium nitrite; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;