Methyl N-<(4S)-4-(4'-methoxyphenyl)but-1-en-4-yl>-(S)-valinate

Base Information

• Chemical Name: Methyl N-<(4S)-4-(4'-methoxyphenyl)but-1-en-4-yl>-(S)-valinate
• CAS No.: 154228-35-0
• Molecular Formula: C₁₇H₂₅NO₃
• Molecular Weight: 291.39
• Mol file: 154228-35-0.mol

Synonyms:Methyl N-<(4S)-4-(4'-methoxyphenyl)but-1-en-4-yl>-(S)-valinate

Chemical Property of Methyl N-<(4S)-4-(4'-methoxyphenyl)but-1-en-4-yl>-(S)-valinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methyl N-<(4S)-4-(4'-methoxyphenyl)but-1-en-4-yl>-(S)-valinate

There total 4 articles about Methyl N-<(4S)-4-(4'-methoxyphenyl)but-1-en-4-yl>-(S)-valinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

Methyl 2--3-methylbutanoate (164122-53-6) + allyl bromide (106-95-6) → Methyl N-<(4S)-4-(4'-methoxyphenyl)but-1-en-4-yl>-(S)-valinate (154228-35-0)

Guidance literature:

With cerium(III) chloride; zinc; In tetrahydrofuran; at 0 ℃; for 1h;

DOI:10.1021/jo0703000

Reference yield:

L-valine methylester hydrochloride (6306-52-1) → Methyl N-<(4S)-4-(4'-methoxyphenyl)but-1-en-4-yl>-(S)-valinate (154228-35-0)

Guidance literature:

Multi-step reaction with 2 steps

1: MgSO₄, Et₃N / tetrahydrofuran / 3 h

2: 100 percent Chromat_. / Zn / tetrahydrofuran / 0.5 h / Ambient temperature

With magnesium sulfate; triethylamine; zinc; In tetrahydrofuran;

DOI:10.1021/jo00104a037

Reference yield:

4-methoxy-benzaldehyde (123-11-5) → Methyl N-<(4S)-4-(4'-methoxyphenyl)but-1-en-4-yl>-(S)-valinate (154228-35-0)

Guidance literature:

Multi-step reaction with 2 steps

1: MgSO₄, Et₃N / tetrahydrofuran / 3 h

2: 100 percent Chromat_. / Zn / tetrahydrofuran / 0.5 h / Ambient temperature

With magnesium sulfate; triethylamine; zinc; In tetrahydrofuran;

DOI:10.1021/jo00104a037

upstream raw materials:

Methyl 2--3-methylbutanoate

allyl bromide

L-valine methylester hydrochloride

4-methoxy-benzaldehyde

Downstream raw materials:

N-[1(S)-(4-methoxyphenyl)-3-buten-1-yl]-(S)-valinol

(S)-N-[1-(4-methoxyphenyl)-3-buten-1-yl]propenamide

(1S)-1-(4-methoxyphenyl)but-3-en-1-amine