(S)-1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-1,2,3.4-tetrahydroisoquinoline hydrochloride

Base Information

Chemical Name:(S)-1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-1,2,3.4-tetrahydroisoquinoline hydrochloride
CAS No.:54417-52-6
Molecular Formula:C₂₀H₂₅NO₄*ClH
Molecular Weight:379.884
Hs Code.:

Synonyms:(S)-1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-1,2,3.4-tetrahydroisoquinoline hydrochloride

Suppliers and Price of (S)-1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-1,2,3.4-tetrahydroisoquinoline hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-1,2,3.4-tetrahydroisoquinoline hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (S)-1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-1,2,3.4-tetrahydroisoquinoline hydrochloride

There total 6 articles about (S)-1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-1,2,3.4-tetrahydroisoquinoline hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₅H₂₆N₂O₆S

: 74-88-4
methyl iodide

: 54417-52-6,66820-84-6
(S)-1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-1,2,3.4-tetrahydroisoquinoline hydrochloride

: 54417-53-7,66820-84-6
(R)-tetrahydropapaverine hydrochloride

Guidance literature:: C₂₅H₂₆N₂O₆S; methyl iodide; With potassium carbonate; In acetonitrile; at 80 ℃; for 18h;

With hydrogenchloride; In ethanol; dichloromethane; water; at 20 ℃; for 24h; Overall yield = 78 %; Overall yield = 48 mg;
DOI:10.1021/acs.joc.5b00509

Reference yield:

: 6957-27-3
3,4-dihydropapaverine

: 54417-52-6,66820-84-6
(S)-1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-1,2,3.4-tetrahydroisoquinoline hydrochloride

: 54417-53-7,66820-84-6
(R)-tetrahydropapaverine hydrochloride

Guidance literature:: With hydrogenchloride; sodium tris[(S)-N-benzyloxycarbonylproline]hydroborate; Yield given. Multistep reaction. Yields of byproduct given; 1.) -30 deg C, in dichloromethane, all reaction time 6h; different reducing agents, reaction times and solvents;
DOI:10.1016/S0040-4039(01)91331-0

Reference yield:

: 5884-22-0
1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-3.4-dihydroisoquinoline hydrochloride

: 54417-52-6,66820-84-6
(S)-1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-1,2,3.4-tetrahydroisoquinoline hydrochloride

Guidance literature:: With formic acid/triethylamine complex 5:2; triethylamine; (p-cymene)ruthenium(II) chloride; N-(2-amino-1,2-diphenyl-ethyl)2,4,6-trimethyl-benzenesulfonamide; In dichloromethane; for 16h; under 760.051 Torr;