methyl 2-amino-5-(4-benzyl-1-piperazinyl)benzoate dihydrochloride

Base Information

• Chemical Name: methyl 2-amino-5-(4-benzyl-1-piperazinyl)benzoate dihydrochloride
• CAS No.: 119198-44-6
• Molecular Formula: C₁₉H₂₃N₃O₂*2ClH
• Molecular Weight: 398.332
• Mol file: 119198-44-6.mol

Synonyms:methyl 2-amino-5-(4-benzyl-1-piperazinyl)benzoate dihydrochloride

Chemical Property of methyl 2-amino-5-(4-benzyl-1-piperazinyl)benzoate dihydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-amino-5-(4-benzyl-1-piperazinyl)benzoate dihydrochloride

There total 2 articles about methyl 2-amino-5-(4-benzyl-1-piperazinyl)benzoate dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

methyl 5-(4-benzyl-1-piperazinyl)-2-nitrobenzoate (119198-42-4) → methyl 2-amino-5-(4-benzyl-1-piperazinyl)benzoate dihydrochloride (119198-44-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; Ambient temperature;

DOI:10.1248/cpb.36.2401

Reference yield:

4-phenyl-1-piperazine (92-54-6) → methyl 2-amino-5-(4-benzyl-1-piperazinyl)benzoate dihydrochloride (119198-44-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 55 percent / dimethylformamide / 6 h / 90 °C

2: 75 percent / H₂ / Pd - C (10percent) / ethanol / Ambient temperature

With hydrogen; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;

DOI:10.1248/cpb.36.2401

Reference yield: 85.0%

methyl 2-amino-5-(4-benzyl-1-piperazinyl)benzoate dihydrochloride (119198-44-6) + trifluoroacetic anhydride (407-25-0) → methyl 5-(4-benzyl-1-piperazinyl)-2-trifluoroacetylaminobenzoate (119198-45-7)

Guidance literature:

With triethylamine; In dichloromethane; for 0.5h; Ambient temperature;

DOI:10.1248/cpb.36.2401

upstream raw materials:

methyl 5-(4-benzyl-1-piperazinyl)-2-nitrobenzoate

4-phenyl-1-piperazine

Downstream raw materials:

methyl 5-(4-benzyl-1-piperazinyl)-2-trifluoroacetylaminobenzoate

methyl 5-(4-benzyl-1-piperazinyl)-2-(N-methylamino)benzoate

6-(4-Benzyl-piperazin-1-yl)-1-methyl-1H-quinazoline-2,4-dione

6-[4-(3,4-Dimethoxy-benzoyl)-piperazin-1-yl]-1-methyl-1H-quinazoline-2,4-dione