isopropyl 4-(5-cyano-4-((2-fluoro-4-(2-methyl-2H-tetrazol-5-yl)phenoxy)methyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

Base Information

• Chemical Name: isopropyl 4-(5-cyano-4-((2-fluoro-4-(2-methyl-2H-tetrazol-5-yl)phenoxy)methyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate
• CAS No.: 1258001-79-4
• Molecular Formula: C₂₂H₂₅FN₈O₃
• Molecular Weight: 468.491

Synonyms:isopropyl 4-(5-cyano-4-((2-fluoro-4-(2-methyl-2H-tetrazol-5-yl)phenoxy)methyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

Chemical Property of isopropyl 4-(5-cyano-4-((2-fluoro-4-(2-methyl-2H-tetrazol-5-yl)phenoxy)methyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of isopropyl 4-(5-cyano-4-((2-fluoro-4-(2-methyl-2H-tetrazol-5-yl)phenoxy)methyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

There total 10 articles about isopropyl 4-(5-cyano-4-((2-fluoro-4-(2-methyl-2H-tetrazol-5-yl)phenoxy)methyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

isopropyl 4-(5-cyano-4-((2-fluoro-4-(2H-tetrazol-5-yl)phenoxy)methyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate (1258001-75-0) + isopropyl 4-(5-cyano-4-((2-fluoro-4-(1H-tetrazol-5-yl)phenoxy)methyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate (1258001-75-0) + methyl iodide (74-88-4) → isopropyl 4-(5-cyano-4-((2-fluoro-4-(1-methyl-1H-tetrazol-5-yl)phenoxy)methyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate (1258001-78-3) + isopropyl 4-(5-cyano-4-((2-fluoro-4-(2-methyl-2H-tetrazol-5-yl)phenoxy)methyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate (1258001-79-4)

Guidance literature:

isopropyl 4-(5-cyano-4-((2-fluoro-4-(2H-tetrazol-5-yl)phenoxy)methyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate; isopropyl 4-(5-cyano-4-((2-fluoro-4-(1H-tetrazol-5-yl)phenoxy)methyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate; With sodium hydride; In tetrahydrofuran; for 0.0833333h;

methyl iodide; In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield: 14.0%

isopropyl 4-(5-cyano-4-((2-fluoro-4-(1H-tetrazol-5-yl)phenoxy)methyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate (1258001-75-0) + methyl iodide (74-88-4) → isopropyl 4-(5-cyano-4-((2-fluoro-4-(1-methyl-1H-tetrazol-5-yl)phenoxy)methyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate (1258001-78-3) + isopropyl 4-(5-cyano-4-((2-fluoro-4-(2-methyl-2H-tetrazol-5-yl)phenoxy)methyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate (1258001-79-4)

Guidance literature:

isopropyl 4-(5-cyano-4-((2-fluoro-4-(1H-tetrazol-5-yl)phenoxy)methyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 0.0833333h;

methyl iodide; In tetrahydrofuran; mineral oil; at 20 ℃; for 16h;

Reference yield:

isopropyl 4-(2-(tert-butoxycarbonyl)hydrazinyl)piperidine-1-carboxylate (1079396-35-2) → isopropyl 4-(5-cyano-4-((2-fluoro-4-(1-methyl-1H-tetrazol-5-yl)phenoxy)methyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate (1258001-78-3) + isopropyl 4-(5-cyano-4-((2-fluoro-4-(2-methyl-2H-tetrazol-5-yl)phenoxy)methyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate (1258001-79-4)

Guidance literature:

Multi-step reaction with 7 steps

1.1: hydrogenchloride; water / ethanol / 4 h / 20 °C / Inert atmosphere

1.2: 14 h / 20 °C

2.1: sodium acetate / ethanol / 3 h / 85 °C

3.1: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 0.5 h / 20 - 65 °C

4.1: dimethylsulfide borane complex / tetrahydrofuran / 25 h / 0 - 20 °C / Reflux

4.2: 0.17 h / 0 - 20 °C

5.1: zinc / 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / ISOPROPYLAMIDE / 1 h / 120 °C / Inert atmosphere; microwave reactor

6.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 20 °C

6.2: 16 h / 20 °C

7.1: sodium hydride / tetrahydrofuran; mineral oil / 0.08 h / 20 °C

7.2: 16 h / 20 °C

With hydrogenchloride; tert.-butylnitrite; dimethylsulfide borane complex; water; sodium acetate; sodium hydride; copper(ll) bromide; zinc; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; ethanol; ISOPROPYLAMIDE; acetonitrile; mineral oil;

upstream raw materials:

isopropyl 4-(5-cyano-4-((2-fluoro-4-(2H-tetrazol-5-yl)phenoxy)methyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

isopropyl 4-(5-cyano-4-((2-fluoro-4-(1H-tetrazol-5-yl)phenoxy)methyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

methyl iodide

3-fluoro-4-hydroxybenzonitrile

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