4-[3-(tert-butyl-diphenyl-silanyloxy)-1-methyl-propyl]-2''-methoxymethoxymethyl-[2,4';2',4'']teroxazole

Base Information

• Chemical Name: 4-[3-(tert-butyl-diphenyl-silanyloxy)-1-methyl-propyl]-2''-methoxymethoxymethyl-[2,4';2',4'']teroxazole
• CAS No.: 477332-11-9
• Molecular Formula: C₃₂H₃₇N₃O₆Si
• Molecular Weight: 587.748

Synonyms:4-[3-(tert-butyl-diphenyl-silanyloxy)-1-methyl-propyl]-2''-methoxymethoxymethyl-[2,4';2',4'']teroxazole

Chemical Property of 4-[3-(tert-butyl-diphenyl-silanyloxy)-1-methyl-propyl]-2''-methoxymethoxymethyl-[2,4';2',4'']teroxazole

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 4-[3-(tert-butyl-diphenyl-silanyloxy)-1-methyl-propyl]-2''-methoxymethoxymethyl-[2,4';2',4'']teroxazole

There total 10 articles about 4-[3-(tert-butyl-diphenyl-silanyloxy)-1-methyl-propyl]-2''-methoxymethoxymethyl-[2,4';2',4'']teroxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2'-Methoxymethoxymethyl-[2,4']bioxazolyl-4-carboxylic acid [(1R,2S)-4-(tert-butyl-diphenyl-silanyloxy)-1-formyl-2-methyl-butyl]-amide → 4-[3-(tert-butyl-diphenyl-silanyloxy)-1-methyl-propyl]-2''-methoxymethoxymethyl-[2,4';2',4'']teroxazole (477332-11-9)

Guidance literature:

2'-Methoxymethoxymethyl-[2,4']bioxazolyl-4-carboxylic acid [(1R,2S)-4-(tert-butyl-diphenyl-silanyloxy)-1-formyl-2-methyl-butyl]-amide; With 2,6-dimethylpyridine; dibromotetrachloroethane; triphenylphosphine;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile;

DOI:10.1016/S0040-4039(02)01553-8

Reference yield:

tert-butylchlorodiphenylsilane (58479-61-1) → 4-[3-(tert-butyl-diphenyl-silanyloxy)-1-methyl-propyl]-2''-methoxymethoxymethyl-[2,4';2',4'']teroxazole (477332-11-9)

Guidance literature:

Multi-step reaction with 8 steps

1.1: 98 percent / imidazole / dimethylformamide

2.1: 82 percent / BCl₃ / toluene

3.1: 94 percent / DCC; DMAP / CH₂Cl₂

4.1: TFA / CH₂Cl₂

5.1: 68 percent / DCC; HOBT / dimethylformamide

6.1: 100 percent / K₂CO₃; MeOH

7.1: Dess-Martin periodinane

8.1: dibromotetrachloroethane; triphenylphosphine; 2,6-lutidine

8.2: 90 percent / DBU / acetonitrile

With 1H-imidazole; 2,6-dimethylpyridine; methanol; dmap; dibromotetrachloroethane; boron trichloride; potassium carbonate; benzotriazol-1-ol; Dess-Martin periodane; dicyclohexyl-carbodiimide; triphenylphosphine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; toluene;

DOI:10.1016/S0040-4039(02)01553-8

Reference yield:

((1R,2S)-1-Benzyloxymethyl-2-methyl-but-3-enyl)-carbamic acid tert-butyl ester (477332-07-3) → 4-[3-(tert-butyl-diphenyl-silanyloxy)-1-methyl-propyl]-2''-methoxymethoxymethyl-[2,4';2',4'']teroxazole (477332-11-9)

Guidance literature:

Multi-step reaction with 9 steps

1.1: 84 percent / 9-BBN; H₂O₂; NaOH

2.1: 98 percent / imidazole / dimethylformamide

3.1: 82 percent / BCl₃ / toluene

4.1: 94 percent / DCC; DMAP / CH₂Cl₂

5.1: TFA / CH₂Cl₂

6.1: 68 percent / DCC; HOBT / dimethylformamide

7.1: 100 percent / K₂CO₃; MeOH

8.1: Dess-Martin periodinane

9.1: dibromotetrachloroethane; triphenylphosphine; 2,6-lutidine

9.2: 90 percent / DBU / acetonitrile

With 1H-imidazole; 2,6-dimethylpyridine; methanol; dmap; sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; dibromotetrachloroethane; dihydrogen peroxide; boron trichloride; potassium carbonate; benzotriazol-1-ol; Dess-Martin periodane; dicyclohexyl-carbodiimide; triphenylphosphine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; toluene;

DOI:10.1016/S0040-4039(02)01553-8

upstream raw materials:

tert-butylchlorodiphenylsilane

((1R,2S)-1-Benzyloxymethyl-2-methyl-but-3-enyl)-carbamic acid tert-butyl ester

((1R,2S)-1-Benzyloxymethyl-4-hydroxy-2-methyl-butyl)-carbamic acid tert-butyl ester

Benzoic acid (2R,3S)-2-amino-5-(tert-butyl-diphenyl-silanyloxy)-3-methyl-pentyl ester

Downstream raw materials:

3-(tert-butyl-diphenyl-silanyloxy)-7-hydroxy-9-(2''-methoxymethoxymethyl-[2,4';2',4'']teroxazol-4-yl)-dec-5-enoic acid tert-butyl ester

3-(tert-butyl-diphenyl-silanyloxy)-9-(2''-methoxymethoxymethyl-[2,4';2',4'']teroxazol-4-yl)-7-oxo-dec-5-enoic acid tert-butyl ester

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