N-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-2-[3-fluoro-4-(1-hydroxycyclopropyl)phenyl]propionamide

Base Information

Chemical Name:N-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-2-[3-fluoro-4-(1-hydroxycyclopropyl)phenyl]propionamide
CAS No.:1402581-38-7
Molecular Formula:C₂₃H₂₀ClF₄N₃O₂
Molecular Weight:481.877
Hs Code.:

Synonyms:N-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-2-[3-fluoro-4-(1-hydroxycyclopropyl)phenyl]propionamide

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Chemical Property of N-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-2-[3-fluoro-4-(1-hydroxycyclopropyl)phenyl]propionamide

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Technology Process of N-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-2-[3-fluoro-4-(1-hydroxycyclopropyl)phenyl]propionamide

There total 13 articles about N-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-2-[3-fluoro-4-(1-hydroxycyclopropyl)phenyl]propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1402585-50-5
2-(4-(1-(tert-butyldimethylsilyloxy)cyclopropyl)-3-fluorophenyl)-N-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)propanamide

: 1402581-38-7
N-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-2-[3-fluoro-4-(1-hydroxycyclopropyl)phenyl]propionamide

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 23 ℃; for 2h;

Reference yield:

: 14763-20-3
3-chlorophenyl hydrazine

: 1402581-38-7
N-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-2-[3-fluoro-4-(1-hydroxycyclopropyl)phenyl]propionamide

Guidance literature:: Multi-step reaction with 6 steps

1: ethanol / 5 h / Reflux

2: N-chloro-succinimide / N,N-dimethyl-formamide / 3.25 h / 23 °C

3: triethylamine / toluene / 20 h / 80 °C

4: hydrogen; ammonia / methanol / 80 °C / 7500.75 Torr

5: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 3.17 h / 23 °C

6: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 23 °C

With N-chloro-succinimide; tetrabutyl ammonium fluoride; ammonia; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 116853-75-9
C₈H₆ClF₃N₂

: 1402581-38-7
N-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-2-[3-fluoro-4-(1-hydroxycyclopropyl)phenyl]propionamide

Guidance literature:: Multi-step reaction with 5 steps

1: N-chloro-succinimide / N,N-dimethyl-formamide / 3.25 h / 23 °C

2: triethylamine / toluene / 20 h / 80 °C

3: hydrogen; ammonia / methanol / 80 °C / 7500.75 Torr

4: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 3.17 h / 23 °C

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 23 °C

With N-chloro-succinimide; tetrabutyl ammonium fluoride; ammonia; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;