2-(4-(1-(tert-butyldimethylsilyloxy)cyclopropyl)-3-fluorophenyl)propanoic acid

Base Information

Chemical Name:2-(4-(1-(tert-butyldimethylsilyloxy)cyclopropyl)-3-fluorophenyl)propanoic acid
CAS No.:1402585-49-2
Molecular Formula:C₁₈H₂₇FO₃Si
Molecular Weight:338.494
Hs Code.:

Synonyms:2-(4-(1-(tert-butyldimethylsilyloxy)cyclopropyl)-3-fluorophenyl)propanoic acid

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Chemical Property of 2-(4-(1-(tert-butyldimethylsilyloxy)cyclopropyl)-3-fluorophenyl)propanoic acid

Chemical Property:

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Technology Process of 2-(4-(1-(tert-butyldimethylsilyloxy)cyclopropyl)-3-fluorophenyl)propanoic acid

There total 7 articles about 2-(4-(1-(tert-butyldimethylsilyloxy)cyclopropyl)-3-fluorophenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1402585-48-1
benzyl 2-(4-(1-(tert-butyldimethylsilyloxy)cyclopropyl)-3-fluorophenyl)acrylate

: 1402585-49-2
2-(4-(1-(tert-butyldimethylsilyloxy)cyclopropyl)-3-fluorophenyl)propanoic acid

Guidance literature:: With 20% palladium hydroxide-activated charcoal; hydrogen; In ethyl acetate; at 23 ℃; for 1h;

Reference yield:

: 112704-79-7
2-fluoro-4-bromobenzoic acid

: 1402585-49-2
2-(4-(1-(tert-butyldimethylsilyloxy)cyclopropyl)-3-fluorophenyl)propanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride / 12.25 h / 0 - 23 °C

2.1: titanium(IV) isopropylate / diethyl ether / 2.25 h / -78 °C

2.2: 16 h / -78 - 23 °C

3.1: 1H-imidazole / dichloromethane / 3 h / 0 °C

4.1: potassium acetate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 3 h / 90 °C / Inert atmosphere

5.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / N,N-dimethyl-formamide / 1 h / 90 - 100 °C / Inert atmosphere

6.1: hydrogen; 20% palladium hydroxide-activated charcoal / ethyl acetate / 1 h / 23 °C

With 1H-imidazole; titanium(IV) isopropylate; bis-triphenylphosphine-palladium(II) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; thionyl chloride; 20% palladium hydroxide-activated charcoal; hydrogen; potassium acetate; caesium carbonate; In 1,4-dioxane; diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1402585-47-0
tert-butyl (1-(2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclopropoxy)dimethylsilane

: 1402585-49-2
2-(4-(1-(tert-butyldimethylsilyloxy)cyclopropyl)-3-fluorophenyl)propanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / N,N-dimethyl-formamide / 1 h / 90 - 100 °C / Inert atmosphere

2: hydrogen; 20% palladium hydroxide-activated charcoal / ethyl acetate / 1 h / 23 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; 20% palladium hydroxide-activated charcoal; hydrogen; caesium carbonate; In ethyl acetate; N,N-dimethyl-formamide;