Technology Process of chloro-1-[1-(4-chloro-phenyl)-3,5-dimethyl-1H-pyrazol-4-yl]-ethanone
There total 6 articles about chloro-1-[1-(4-chloro-phenyl)-3,5-dimethyl-1H-pyrazol-4-yl]-ethanone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1-(4-chloro-phenyl)-3,5-dimethyl-1H-pyrazole-4-carboxylic acid;
With
thionyl chloride;
for 8h;
Reflux;
diazomethyl-trimethyl-silane;
In
acetonitrile;
at 0 - 20 ℃;
for 18h;
Inert atmosphere;
With
hydrogenchloride;
In
water; acetonitrile;
at 0 - 20 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: N-ethyl-N,N-diisopropylamine / copper diacetate / dichloromethane / 18 h / 55 °C / Inert atmosphere; Sealed tube
2.1: trichlorophosphate / 0.25 h / 0 °C / Inert atmosphere
2.2: 18 h / 0 - 70 °C
3.1: Jones reagent / acetone / 4 h / 0 - 20 °C
4.1: thionyl chloride / 8 h / Reflux
4.2: 18 h / 0 - 20 °C / Inert atmosphere
4.3: 2 h / 0 - 20 °C
With
Jones reagent; thionyl chloride; N-ethyl-N,N-diisopropylamine; trichlorophosphate;
copper diacetate;
In
dichloromethane; acetone;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: N-ethyl-N,N-diisopropylamine / copper diacetate / dichloromethane / 18 h / 55 °C / Inert atmosphere; Sealed tube
2.1: trichlorophosphate / 0.25 h / 0 °C / Inert atmosphere
2.2: 18 h / 0 - 70 °C
3.1: Jones reagent / acetone / 4 h / 0 - 20 °C
4.1: thionyl chloride / 8 h / Reflux
4.2: 18 h / 0 - 20 °C / Inert atmosphere
4.3: 2 h / 0 - 20 °C
With
Jones reagent; thionyl chloride; N-ethyl-N,N-diisopropylamine; trichlorophosphate;
copper diacetate;
In
dichloromethane; acetone;
