(E)-5-(benzyloxyimino)-2,3,4,5-tetrahydroazepino[3,4-b]indol-1(10H)-one

Base Information

Chemical Name:(E)-5-(benzyloxyimino)-2,3,4,5-tetrahydroazepino[3,4-b]indol-1(10H)-one
CAS No.:1413996-38-9
Molecular Formula:C₁₉H₁₇N₃O₂
Molecular Weight:319.363
Hs Code.:

Synonyms:(E)-5-(benzyloxyimino)-2,3,4,5-tetrahydroazepino[3,4-b]indol-1(10H)-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-5-(benzyloxyimino)-2,3,4,5-tetrahydroazepino[3,4-b]indol-1(10H)-one

Chemical Property:

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Technology Process of (E)-5-(benzyloxyimino)-2,3,4,5-tetrahydroazepino[3,4-b]indol-1(10H)-one

There total 4 articles about (E)-5-(benzyloxyimino)-2,3,4,5-tetrahydroazepino[3,4-b]indol-1(10H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 622-33-3
N-benzyloxyamine

: 68724-84-5
3,4-dihydroazepino[3,4-b]indole-1,5-(2H,10H)-dione

: 1413996-38-9
(E)-5-(benzyloxyimino)-2,3,4,5-tetrahydroazepino[3,4-b]indol-1(10H)-one

Guidance literature:: With pyridine; boron trifluoride diethyl etherate; In tetrahydrofuran; at -10 - 20 ℃; for 49h; Inert atmosphere;
DOI:10.1016/j.ejmech.2012.08.022

Reference yield:

: 68724-78-7
3-[(1H-indole-2-carbonyl)amino]propionic acid ethyl ester

: 1413996-38-9
(E)-5-(benzyloxyimino)-2,3,4,5-tetrahydroazepino[3,4-b]indol-1(10H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hydroxide monohydrate / tetrahydrofuran / Reflux

2: methanesulfonic acid; phosphorus pentoxide / 80 °C

3: boron trifluoride diethyl etherate; pyridine / tetrahydrofuran / 49 h / -10 - 20 °C / Inert atmosphere

With pyridine; methanesulfonic acid; lithium hydroxide monohydrate; phosphorus pentoxide; boron trifluoride diethyl etherate; In tetrahydrofuran;
DOI:10.1016/j.ejmech.2012.08.022

Reference yield:

Indole-2-carboxylic acid: 1477-50-5,1228050-17-6
Indole-2-carboxylic acid

: 1413996-38-9
(E)-5-(benzyloxyimino)-2,3,4,5-tetrahydroazepino[3,4-b]indol-1(10H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 24 h / 0 - 20 °C

2: lithium hydroxide monohydrate / tetrahydrofuran / Reflux

3: methanesulfonic acid; phosphorus pentoxide / 80 °C

4: boron trifluoride diethyl etherate; pyridine / tetrahydrofuran / 49 h / -10 - 20 °C / Inert atmosphere

With pyridine; dmap; methanesulfonic acid; lithium hydroxide monohydrate; phosphorus pentoxide; boron trifluoride diethyl etherate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.ejmech.2012.08.022