Technology Process of 4-fluoro-2'-iodo-acetophenone
There total 4 articles about 4-fluoro-2'-iodo-acetophenone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
copper(l) iodide; Trimethylenediamine; sodium iodide;
In
1,4-dioxane;
for 24h;
Reflux;
Inert atmosphere;
DOI:10.1155/2019/2385064
- Guidance literature:
-
malonic acid dimethyl ester;
With
triethylamine; magnesium chloride;
In
acetonitrile;
at 0 ℃;
for 0.75h;
Inert atmosphere;
2-iodo-4-fluorobenzoyl chloride;
In
acetonitrile;
at 0 - 20 ℃;
for 3h;
Inert atmosphere;
With
lithium chloride;
In
water; N,N-dimethyl-formamide;
at 100 ℃;
for 4h;
Inert atmosphere;
DOI:10.1002/anie.201813202
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
2.1: magnesium chloride; triethylamine / acetonitrile / 0.75 h / 0 °C / Inert atmosphere
2.2: 3 h / 0 - 20 °C / Inert atmosphere
2.3: 4 h / 100 °C / Inert atmosphere
With
oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; magnesium chloride;
In
dichloromethane; acetonitrile;
DOI:10.1002/anie.201813202
