ethyl 3-((5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)-4,4-dimethylhexanoate

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Chemical Name:ethyl 3-((5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)-4,4-dimethylhexanoate
CAS No.:1422051-84-0
Molecular Formula:C₂₈H₃₁F₂N₅O₄S
Molecular Weight:571.648
Hs Code.:

Synonyms:ethyl 3-((5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)-4,4-dimethylhexanoate

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Chemical Property of ethyl 3-((5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)-4,4-dimethylhexanoate

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Technology Process of ethyl 3-((5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)-4,4-dimethylhexanoate

There total 9 articles about ethyl 3-((5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)-4,4-dimethylhexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1259279-58-7
5-fluoro-3-(5-fluoro-4-methylsulfinyl-pyrimidin-2-yl)-1-(p-tolylsulfonyl)-pyrrolo[2,3-b]pyridine

: 1422051-83-9
ethyl 3-amino-4,4-dimethylhexanoate

: 1422051-84-0
ethyl 3-((5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)-4,4-dimethylhexanoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 80 ℃;

Reference yield:

: 1417421-99-8
3-bromo-5-fluoro-1-(p-toluenesulfonyl)-1H-pyrrolo[2,3-b]pyridine

: 1422051-84-0
ethyl 3-((5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)-4,4-dimethylhexanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium acetate / water; 1,4-dioxane / 0.5 h / Inert atmosphere

1.2: Inert atmosphere; Reflux

2.1: sodium carbonate / water; 1,2-dimethoxyethane / 0.33 h / Inert atmosphere

2.2: Inert atmosphere; Reflux

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3.5 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 80 °C

With potassium acetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water;

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 1422051-84-0
ethyl 3-((5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)-4,4-dimethylhexanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C

1.2: 2 h / 0 - 20 °C

2.1: potassium acetate / water; 1,4-dioxane / 0.5 h / Inert atmosphere

2.2: Inert atmosphere; Reflux

3.1: sodium carbonate / water; 1,2-dimethoxyethane / 0.33 h / Inert atmosphere

3.2: Inert atmosphere; Reflux

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3.5 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 80 °C

With potassium acetate; sodium hydride; sodium carbonate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;