2 3-DIMETHOXY-1-NAPHTHALDEHYDE 97

Base Information

• Chemical Name: 2 3-DIMETHOXY-1-NAPHTHALDEHYDE 97
• CAS No.: 56252-09-6
• Molecular Formula: C13H12O3
• Molecular Weight: 216.236
• Hs Code.: 2912499000
• European Community (EC) Number: 624-099-0
• DSSTox Substance ID: DTXSID60540578
• Wikidata: Q82416624
• Mol file: 56252-09-6.mol

Synonyms:2 3-DIMETHOXY-1-NAPHTHALDEHYDE 97

Chemical Property of 2 3-DIMETHOXY-1-NAPHTHALDEHYDE 97

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 79-83 °C(lit.)
• Refractive Index: 1.618
• Boiling Point: 214-215 °C15 mm Hg(lit.)
• Flash Point: 171.655°C
• PSA: 35.53000
• Density: 1.18g/cm³
• LogP: 2.66950
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 216.078644241
• Heavy Atom Count: 16
• Complexity: 241

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,3-Dimethoxy-1-naphthaldehyde 97% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC2=CC=CC=C2C(=C1OC)C=O

Technology Process of 2 3-DIMETHOXY-1-NAPHTHALDEHYDE 97

There total 4 articles about 2 3-DIMETHOXY-1-NAPHTHALDEHYDE 97 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.5%

2,3-Dihydroxy-1-naphthaldehyde (2089-80-7) + methyl iodide (74-88-4) → 2,3-Dimethoxy-naphthalene-1-carbaldehyde (56252-09-6)

Guidance literature:

With potassium carbonate; In acetone; for 8h; Heating;

DOI:10.1016/S0960-894X(97)00100-5

Reference yield: 61.0%

difluoromethyl phenyl sulfide (1535-67-7) + 2,3-dimethoxynaphthalene (10103-06-7) → 6,7-dimethoxy-2-naphthaldehyde (66920-80-7) + 2,3-Dimethoxy-naphthalene-1-carbaldehyde (56252-09-6)

Guidance literature:

difluoromethyl phenyl sulfide; 2,3-dimethoxynaphthalene; With tin(IV) chloride; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In water; dimethyl sulfoxide; at 20 ℃; for 2h;

DOI:10.1055/s-0036-1591545

Reference yield:

2,3-Dihydroxy-1-naphthaldehyde (2089-80-7) + methyl iodide (74-88-4) → 2,3-Dimethoxy-naphthalene-1-carbaldehyde (56252-09-6) + 3-Hydroxy-2-methoxy-1-naphthaldehyde

Guidance literature:

With potassium carbonate; In acetone; Heating;

DOI:10.1039/c39850000502

upstream raw materials:

2,3-Dihydroxy-1-naphthaldehyde

methyl iodide

dimethyl sulfate

difluoromethyl phenyl sulfide

Refernces

• 1、 Betterley, Nolan M.,Kongsriprapan, Sopanat,Chaturonrutsamee, Suppisak,Deelertpaiboon, Pramchai,Surawatanawong, Panida,Pohmakotr, Manat,Soorukram, Darunee,Reutrakul, Vichai,Kuhakarn, Chutima. "Electrophilic Aromatic Formylation with Difluoro(phenylsulfanyl) methane". . p. 2033 - 2040. Retrieved 2018/03/21.
• 2、 Kimachi, Tetsutaro,Sugita, Ken-Ichi,Tamura, Yoshinori,Kagawa, Miyuki,Yamasaki, Kumi,Yoneda, Fumio,Sasaki, Takuma. "Synthesis and cytotoxicity of 5-deazaflavins containing o- and p-quinone moieties". . p. 753 - 756. Retrieved 2007/10/03.