1-(ethoxymethyl)-5-methyl-9-phenyl-8,9-dihydro-1H-pyrimido[4,5-b][1,4]diazepine-2,4,6(3H,5H,7H)-trione

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Chemical Name:1-(ethoxymethyl)-5-methyl-9-phenyl-8,9-dihydro-1H-pyrimido[4,5-b][1,4]diazepine-2,4,6(3H,5H,7H)-trione
CAS No.:1398113-69-3
Molecular Formula:C₁₇H₂₀N₄O₄
Molecular Weight:344.37
Hs Code.:

Synonyms:1-(ethoxymethyl)-5-methyl-9-phenyl-8,9-dihydro-1H-pyrimido[4,5-b][1,4]diazepine-2,4,6(3H,5H,7H)-trione

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Chemical Property of 1-(ethoxymethyl)-5-methyl-9-phenyl-8,9-dihydro-1H-pyrimido[4,5-b][1,4]diazepine-2,4,6(3H,5H,7H)-trione

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Technology Process of 1-(ethoxymethyl)-5-methyl-9-phenyl-8,9-dihydro-1H-pyrimido[4,5-b][1,4]diazepine-2,4,6(3H,5H,7H)-trione

There total 4 articles about 1-(ethoxymethyl)-5-methyl-9-phenyl-8,9-dihydro-1H-pyrimido[4,5-b][1,4]diazepine-2,4,6(3H,5H,7H)-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1398113-66-0
5-methyl-9-phenyl-8,9-dihydro-1H-pyrimido[4,5-b][1,4]diazepine-2,4,6(3H,5H,7H)-trione

: 3188-13-4
ethyl chloromethyl ether

: 1398113-69-3
1-(ethoxymethyl)-5-methyl-9-phenyl-8,9-dihydro-1H-pyrimido[4,5-b][1,4]diazepine-2,4,6(3H,5H,7H)-trione

Guidance literature:: With N,O-bis-(trimethylsilyl)-acetamide; In chloroform;
DOI:10.1016/j.tetlet.2012.06.143

Reference yield:

: 1398113-56-8
methyl 3-((2,6-dimethoxy-5-nitropyrimidin-4-yl)(phenyl)amino)propanoate

: 1398113-69-3
1-(ethoxymethyl)-5-methyl-9-phenyl-8,9-dihydro-1H-pyrimido[4,5-b][1,4]diazepine-2,4,6(3H,5H,7H)-trione

Guidance literature:: Multi-step reaction with 4 steps

1: sodium dithionite / ethanol; water / 6 h / Reflux

2: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 20 °C

3: chloro-trimethyl-silane; sodium iodide / acetonitrile / 24 h / 20 °C / Inert atmosphere

4: N,O-bis-(trimethylsilyl)-acetamide / chloroform

With chloro-trimethyl-silane; sodium dithionite; N,O-bis-(trimethylsilyl)-acetamide; sodium hydride; sodium iodide; In tetrahydrofuran; ethanol; chloroform; water; acetonitrile; mineral oil;
DOI:10.1016/j.tetlet.2012.06.143

Reference yield:

: 21911-84-2
methyl 3-(phenylamino)propanoate

: 1398113-69-3
1-(ethoxymethyl)-5-methyl-9-phenyl-8,9-dihydro-1H-pyrimido[4,5-b][1,4]diazepine-2,4,6(3H,5H,7H)-trione

Guidance literature:: Multi-step reaction with 5 steps

1: tert-butyl alcohol / 8 h / Reflux

2: sodium dithionite / ethanol; water / 6 h / Reflux

3: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 20 °C

4: chloro-trimethyl-silane; sodium iodide / acetonitrile / 24 h / 20 °C / Inert atmosphere

5: N,O-bis-(trimethylsilyl)-acetamide / chloroform

With chloro-trimethyl-silane; sodium dithionite; N,O-bis-(trimethylsilyl)-acetamide; sodium hydride; sodium iodide; In tetrahydrofuran; ethanol; chloroform; water; acetonitrile; mineral oil; tert-butyl alcohol;
DOI:10.1016/j.tetlet.2012.06.143