2-chloro-4,4-difluoro-1'-[[1-(2-fluoro-6-nitro-phenyl)-3-methyl-pyrazol-4-yl]methyl]spiro[5H-thieno[2,3-c]pyran-7,4'-piperidine]

Base Information

Chemical Name:2-chloro-4,4-difluoro-1'-[[1-(2-fluoro-6-nitro-phenyl)-3-methyl-pyrazol-4-yl]methyl]spiro[5H-thieno[2,3-c]pyran-7,4'-piperidine]
CAS No.:1307314-64-2
Molecular Formula:C₂₂H₂₀ClF₃N₄O₃S
Molecular Weight:512.94
Hs Code.:

Synonyms:2-chloro-4,4-difluoro-1'-[[1-(2-fluoro-6-nitro-phenyl)-3-methyl-pyrazol-4-yl]methyl]spiro[5H-thieno[2,3-c]pyran-7,4'-piperidine]

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Chemical Property of 2-chloro-4,4-difluoro-1'-[[1-(2-fluoro-6-nitro-phenyl)-3-methyl-pyrazol-4-yl]methyl]spiro[5H-thieno[2,3-c]pyran-7,4'-piperidine]

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Technology Process of 2-chloro-4,4-difluoro-1'-[[1-(2-fluoro-6-nitro-phenyl)-3-methyl-pyrazol-4-yl]methyl]spiro[5H-thieno[2,3-c]pyran-7,4'-piperidine]

There total 10 articles about 2-chloro-4,4-difluoro-1'-[[1-(2-fluoro-6-nitro-phenyl)-3-methyl-pyrazol-4-yl]methyl]spiro[5H-thieno[2,3-c]pyran-7,4'-piperidine] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6921-22-8
1,2-difluoro-3-nitrobenzene

: 1307248-44-7
2-chloro-4,4-difluoro-4,5-dihydrospiro[5H-thieno[2,3-c]pyran-7,4'-piperidine]

: 112758-40-4
3-methyl-1H-pyrazole-4-carbaldehyde

: 1307314-64-2
2-chloro-4,4-difluoro-1'-[[1-(2-fluoro-6-nitro-phenyl)-3-methyl-pyrazol-4-yl]methyl]spiro[5H-thieno[2,3-c]pyran-7,4'-piperidine]

: C₂₂H₂₀ClF₃N₄O₃S

Guidance literature:: 1,2-difluoro-3-nitrobenzene; 3-methyl-1H-pyrazole-4-carbaldehyde; With potassium carbonate; In acetonitrile; at 20 ℃;

2-chloro-4,4-difluoro-4,5-dihydrospiro[5H-thieno[2,3-c]pyran-7,4'-piperidine]; In dichloromethane; at 20 ℃; for 0.5h;

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃;

Reference yield:

: 1307248-46-9
tert-butyl-2′-chloro-4′-oxo-4′,5′-dihydrospiro[piperidine-4,7′-thieno[2,3-c]pyran]-1-carboxylate

: 1307314-64-2
2-chloro-4,4-difluoro-1'-[[1-(2-fluoro-6-nitro-phenyl)-3-methyl-pyrazol-4-yl]methyl]spiro[5H-thieno[2,3-c]pyran-7,4'-piperidine]

: C₂₂H₂₀ClF₃N₄O₃S

Guidance literature:: Multi-step reaction with 3 steps

1.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / tetrahydrofuran / 24 h / 70 °C

2.1: hydrogenchloride / isopropyl alcohol; water / 15 h / 45 °C

3.1: potassium carbonate / acetonitrile / 20 °C

3.2: 0.5 h / 20 °C

3.3: 20 °C

With hydrogenchloride; potassium carbonate; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In tetrahydrofuran; water; isopropyl alcohol; acetonitrile;

Reference yield:

: 1283095-47-5
4′,5′-dihydrospiro[piperidine-4,7′-thieno[2,3-c]pyran]

: 1307314-64-2
2-chloro-4,4-difluoro-1'-[[1-(2-fluoro-6-nitro-phenyl)-3-methyl-pyrazol-4-yl]methyl]spiro[5H-thieno[2,3-c]pyran-7,4'-piperidine]

: C₂₂H₂₀ClF₃N₄O₃S

Guidance literature:: Multi-step reaction with 8 steps

1.1: acetic acid; sulfuryl dichloride / tert-butyl methyl ether / 21.17 h / 15 - 22 °C

2.1: dmap; triethylamine / dichloromethane / 20 °C

3.1: N-Bromosuccinimide / chlorobenzene / 19 h / 20 - 45 °C / Irradiation

4.1: sodium hydrogencarbonate; dimethyl sulfoxide / chlorobenzene / 24 h / 20 °C

5.1: sodium hydrogencarbonate; sodium hypochlorite; potassium bromide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane; chlorobenzene; water / 2 h / 5 - 20 °C

6.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / tetrahydrofuran / 24 h / 70 °C

7.1: hydrogenchloride / isopropyl alcohol; water / 15 h / 45 °C

8.1: potassium carbonate / acetonitrile / 20 °C

8.2: 0.5 h / 20 °C

8.3: 20 °C

With hydrogenchloride; dmap; sodium hypochlorite; N-Bromosuccinimide; sulfuryl dichloride; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; potassium carbonate; acetic acid; dimethyl sulfoxide; triethylamine; potassium bromide; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In tetrahydrofuran; dichloromethane; tert-butyl methyl ether; water; chlorobenzene; isopropyl alcohol; acetonitrile;