2-[(2-bromophenyl)ethynyl]benzothiopheneyl-3-boronic acid 2,2-dimethylpropane-1,3-diyl ester

Base Information

• Chemical Name: 2-[(2-bromophenyl)ethynyl]benzothiopheneyl-3-boronic acid 2,2-dimethylpropane-1,3-diyl ester
• CAS No.: 1300008-99-4
• Molecular Formula: C₂₁H₁₈BBrO₂S
• Molecular Weight: 425.154

Synonyms:2-[(2-bromophenyl)ethynyl]benzothiopheneyl-3-boronic acid 2,2-dimethylpropane-1,3-diyl ester

Chemical Property of 2-[(2-bromophenyl)ethynyl]benzothiopheneyl-3-boronic acid 2,2-dimethylpropane-1,3-diyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(2-bromophenyl)ethynyl]benzothiopheneyl-3-boronic acid 2,2-dimethylpropane-1,3-diyl ester

There total 2 articles about 2-[(2-bromophenyl)ethynyl]benzothiopheneyl-3-boronic acid 2,2-dimethylpropane-1,3-diyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

Trimethyl borate (121-43-7,63156-11-6) + 3-bromo-2-((2-bromophenyl)ethynyl)benzo[b]thiophene (1245602-60-1) + 2,2-Dimethyl-1,3-propanediol (126-30-7) → 2-[(2-bromophenyl)ethynyl]benzothiopheneyl-3-boronic acid 2,2-dimethylpropane-1,3-diyl ester (1300008-99-4)

Guidance literature:

3-bromo-2-((2-bromophenyl)ethynyl)benzo[b]thiophene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; Inert atmosphere;

Trimethyl borate; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 2.5h; Inert atmosphere;

2,2-Dimethyl-1,3-propanediol; In tetrahydrofuran; hexane; at 70 ℃; for 1h; Inert atmosphere;

DOI:10.1021/ja2019977

Reference yield:

2-iodo-3-bromo-benzo[b]thiophene (140898-76-6) → 2-[(2-bromophenyl)ethynyl]benzothiopheneyl-3-boronic acid 2,2-dimethylpropane-1,3-diyl ester (1300008-99-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran; triethylamine / 24 h / 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C / Inert atmosphere

2.2: 2.5 h / -78 - 20 °C / Inert atmosphere

2.3: 1 h / 70 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; n-butyllithium; In tetrahydrofuran; hexane; triethylamine;

DOI:10.1021/ja2019977

Reference yield: 23.0%

2-[(2-bromophenyl)ethynyl]benzothiopheneyl-3-boronic acid 2,2-dimethylpropane-1,3-diyl ester (1300008-99-4) + (2,4,6-triisopropylphenyl)magnesium bromide (108894-99-1) → (Me2C(OCH2)2)[B(2,4,6-triisopropylphenyl)C8H4SCCC6H4Br]2 (1300009-01-1)

Guidance literature:

In tetrahydrofuran; at 0 ℃; for 2.5h; Reflux; Inert atmosphere;

DOI:10.1021/ja2019977

upstream raw materials:

2-iodo-3-bromo-benzo[b]thiophene

Trimethyl borate

3-bromo-2-((2-bromophenyl)ethynyl)benzo[b]thiophene

2,2-Dimethyl-1,3-propanediol

Downstream raw materials:

(Me₂C(OCH₂)2)[B(2,4,6-triisopropylphenyl)C₈H₄SCCC₆H₄Br]2

B-(2,4,6-triisopropylphenyl)bis(benzothieno)[3,2-b:2',3'-d]borole

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

✦Write with AI

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1300008-99-4 2-[(2-bromophenyl)ethynyl]benzothiopheneyl-3-boronic acid 2,2-dimethylpropane-1,3-diyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send