α-methanesulfonyloxy-p-bromoacetophenone

Base Information

• Chemical Name: α-methanesulfonyloxy-p-bromoacetophenone
• CAS No.: 19826-89-2
• Molecular Formula: C₉H₉BrO₄S
• Molecular Weight: 293.138
• Mol file: 19826-89-2.mol

Synonyms:α-methanesulfonyloxy-p-bromoacetophenone

Chemical Property of α-methanesulfonyloxy-p-bromoacetophenone

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of α-methanesulfonyloxy-p-bromoacetophenone

There total 7 articles about α-methanesulfonyloxy-p-bromoacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

4-bromo-1-ethynylbenzene (766-96-1) + methanesulfonic acid (75-75-2,98527-29-8) + acetic acid (64-19-7,77671-22-8) → 2-(4-bromophenyl)-2-oxoethyl acetate (7500-37-0) + α-methanesulfonyloxy-p-bromoacetophenone (19826-89-2)

Guidance literature:

With 8-methylquinoline 1-oxide; [bis(trifluoromethanesulfonyl)imidate](triphenylphosphine)gold(I); at 20 ℃; for 8h;

DOI:10.1055/s-0033-1338513

Reference yield: 72.0%

4-bromo-1-ethynylbenzene (766-96-1) + methanesulfonic acid (75-75-2,98527-29-8) → α-methanesulfonyloxy-p-bromoacetophenone (19826-89-2)

Guidance literature:

With 3,5-dicholoropyridine N-oxide; (Cy₃P)AuNTf₂; In chlorobenzene; at 20 ℃; for 8h;

DOI:10.1055/s-0033-1339337

Reference yield: 51.0%

methanesulfonic acid (75-75-2,98527-29-8) + para-bromoacetophenone (99-90-1) → α-methanesulfonyloxy-p-bromoacetophenone (19826-89-2)

Guidance literature:

With potassium peroxymonosulfate; iodine; In 2,2,2-trifluoroethanol; acetonitrile; at 60 ℃; for 24h; Inert atmosphere;

DOI:10.1055/s-0032-1318199

upstream raw materials:

methanesulfonic acid

1-(4-bromo-phenyl)-2-diazo-ethanone

1-(3,4-dimethoxyphenyl)-2-(methoxyphenoxy)propane-1,3-diol

para-bromophenacyl bromide

Downstream raw materials:

1-(4-bromophenyl)-2-thiocyanatoethanone