tert-butyl N-[5-(5-{5-[4-(benzyloxy)-3-chlorophenyl]-1,2,4-oxadiazol-3-yl}-1-benzofuran-2-yl)-2,2-dimethyl-1,3-dioxan-5-yl]carbamate

Base Information

Chemical Name:tert-butyl N-[5-(5-{5-[4-(benzyloxy)-3-chlorophenyl]-1,2,4-oxadiazol-3-yl}-1-benzofuran-2-yl)-2,2-dimethyl-1,3-dioxan-5-yl]carbamate
CAS No.:1608147-62-1
Molecular Formula:C₃₄H₃₄ClN₃O₇
Molecular Weight:632.113
Hs Code.:

Synonyms:tert-butyl N-[5-(5-{5-[4-(benzyloxy)-3-chlorophenyl]-1,2,4-oxadiazol-3-yl}-1-benzofuran-2-yl)-2,2-dimethyl-1,3-dioxan-5-yl]carbamate

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Chemical Property of tert-butyl N-[5-(5-{5-[4-(benzyloxy)-3-chlorophenyl]-1,2,4-oxadiazol-3-yl}-1-benzofuran-2-yl)-2,2-dimethyl-1,3-dioxan-5-yl]carbamate

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Technology Process of tert-butyl N-[5-(5-{5-[4-(benzyloxy)-3-chlorophenyl]-1,2,4-oxadiazol-3-yl}-1-benzofuran-2-yl)-2,2-dimethyl-1,3-dioxan-5-yl]carbamate

There total 9 articles about tert-butyl N-[5-(5-{5-[4-(benzyloxy)-3-chlorophenyl]-1,2,4-oxadiazol-3-yl}-1-benzofuran-2-yl)-2,2-dimethyl-1,3-dioxan-5-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1608147-58-5
tert-butyl N-(5-{5-[5-(3-chloro-4-hydroxyphenyl)-1,2,4-oxadiazol-3-yl]-1-benzofuran-2-yl}-2,2-dimethyl-1,3-dioxan-5-yl)carbamate

: 100-39-0
benzyl bromide

: 1608147-62-1
tert-butyl N-[5-(5-{5-[4-(benzyloxy)-3-chlorophenyl]-1,2,4-oxadiazol-3-yl}-1-benzofuran-2-yl)-2,2-dimethyl-1,3-dioxan-5-yl]carbamate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 3h; Inert atmosphere;

Reference yield:

: 59595-94-7
3?chloro?4-hydroxybenzoyl chloride

: 1608147-62-1
tert-butyl N-[5-(5-{5-[4-(benzyloxy)-3-chlorophenyl]-1,2,4-oxadiazol-3-yl}-1-benzofuran-2-yl)-2,2-dimethyl-1,3-dioxan-5-yl]carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / -5 - 20 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride / dimethyl sulfoxide; tetrahydrofuran / 1 h / 110 °C / Inert atmosphere

3: boron trichloride / dichloromethane / 20 °C

4: copper(I) oxide; pyridine / 1 h / 110 °C / Inert atmosphere

5: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

With pyridine; copper(I) oxide; tetrabutyl ammonium fluoride; boron trichloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 3964-58-7
3-chloro-4-hydroxybenzoic acid

: 1608147-62-1
tert-butyl N-[5-(5-{5-[4-(benzyloxy)-3-chlorophenyl]-1,2,4-oxadiazol-3-yl}-1-benzofuran-2-yl)-2,2-dimethyl-1,3-dioxan-5-yl]carbamate

Guidance literature:: Multi-step reaction with 6 steps

1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 2 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / -5 - 20 °C / Inert atmosphere

3: tetrabutyl ammonium fluoride / dimethyl sulfoxide; tetrahydrofuran / 1 h / 110 °C / Inert atmosphere

4: boron trichloride / dichloromethane / 20 °C

5: copper(I) oxide; pyridine / 1 h / 110 °C / Inert atmosphere

6: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

With pyridine; copper(I) oxide; oxalyl dichloride; tetrabutyl ammonium fluoride; boron trichloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;