tert-butyl N-(5-{5-[5-(3-chloro-4-hydroxyphenyl)-1,2,4-oxadiazol-3-yl]-1-benzofuran-2-yl}-2,2-dimethyl-1,3-dioxan-5-yl)carbamate

Base Information

Chemical Name:tert-butyl N-(5-{5-[5-(3-chloro-4-hydroxyphenyl)-1,2,4-oxadiazol-3-yl]-1-benzofuran-2-yl}-2,2-dimethyl-1,3-dioxan-5-yl)carbamate
CAS No.:1608147-58-5
Molecular Formula:C₂₇H₂₈ClN₃O₇
Molecular Weight:541.988
Hs Code.:

Synonyms:tert-butyl N-(5-{5-[5-(3-chloro-4-hydroxyphenyl)-1,2,4-oxadiazol-3-yl]-1-benzofuran-2-yl}-2,2-dimethyl-1,3-dioxan-5-yl)carbamate

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Chemical Property of tert-butyl N-(5-{5-[5-(3-chloro-4-hydroxyphenyl)-1,2,4-oxadiazol-3-yl]-1-benzofuran-2-yl}-2,2-dimethyl-1,3-dioxan-5-yl)carbamate

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Technology Process of tert-butyl N-(5-{5-[5-(3-chloro-4-hydroxyphenyl)-1,2,4-oxadiazol-3-yl]-1-benzofuran-2-yl}-2,2-dimethyl-1,3-dioxan-5-yl)carbamate

There total 8 articles about tert-butyl N-(5-{5-[5-(3-chloro-4-hydroxyphenyl)-1,2,4-oxadiazol-3-yl]-1-benzofuran-2-yl}-2,2-dimethyl-1,3-dioxan-5-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1608147-56-3
2-chloro-4-(3-(4-hydroxy-3-iodophenyl)-1,2,4-oxadiazol-5-yl)phenol

: 364631-74-3
5-ethynyl-2,2-dimethyl-[1,3]dioxan-(N-tert-butyloxycarbonyl)-5-ylamine

: 1608147-58-5
tert-butyl N-(5-{5-[5-(3-chloro-4-hydroxyphenyl)-1,2,4-oxadiazol-3-yl]-1-benzofuran-2-yl}-2,2-dimethyl-1,3-dioxan-5-yl)carbamate

Guidance literature:: With pyridine; copper(I) oxide; at 110 ℃; for 1h; Inert atmosphere;

Reference yield:

: 3964-58-7
3-chloro-4-hydroxybenzoic acid

: 1608147-58-5
tert-butyl N-(5-{5-[5-(3-chloro-4-hydroxyphenyl)-1,2,4-oxadiazol-3-yl]-1-benzofuran-2-yl}-2,2-dimethyl-1,3-dioxan-5-yl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 2 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / -5 - 20 °C / Inert atmosphere

3: tetrabutyl ammonium fluoride / dimethyl sulfoxide; tetrahydrofuran / 1 h / 110 °C / Inert atmosphere

4: boron trichloride / dichloromethane / 20 °C

5: copper(I) oxide; pyridine / 1 h / 110 °C / Inert atmosphere

With pyridine; copper(I) oxide; oxalyl dichloride; tetrabutyl ammonium fluoride; boron trichloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1220973-38-5
N-hydroxy-3-iodo-4-isopropoxybenzimidamide

: 1608147-58-5
tert-butyl N-(5-{5-[5-(3-chloro-4-hydroxyphenyl)-1,2,4-oxadiazol-3-yl]-1-benzofuran-2-yl}-2,2-dimethyl-1,3-dioxan-5-yl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / -5 - 20 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride / dimethyl sulfoxide; tetrahydrofuran / 1 h / 110 °C / Inert atmosphere

3: boron trichloride / dichloromethane / 20 °C

4: copper(I) oxide; pyridine / 1 h / 110 °C / Inert atmosphere

With pyridine; copper(I) oxide; tetrabutyl ammonium fluoride; boron trichloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;