ethyl 6-([tert-butyl(diphenyl)silyl]oxy)-9-(cyclopropylmethoxy)-benzo[h]quinoline-2-carboxylate

Base Information

Chemical Name:ethyl 6-([tert-butyl(diphenyl)silyl]oxy)-9-(cyclopropylmethoxy)-benzo[h]quinoline-2-carboxylate
CAS No.:958219-75-5
Molecular Formula:C₃₆H₃₇NO₄Si
Molecular Weight:575.78
Hs Code.:

Synonyms:ethyl 6-([tert-butyl(diphenyl)silyl]oxy)-9-(cyclopropylmethoxy)-benzo[h]quinoline-2-carboxylate

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Chemical Property of ethyl 6-([tert-butyl(diphenyl)silyl]oxy)-9-(cyclopropylmethoxy)-benzo[h]quinoline-2-carboxylate

Chemical Property:

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Technology Process of ethyl 6-([tert-butyl(diphenyl)silyl]oxy)-9-(cyclopropylmethoxy)-benzo[h]quinoline-2-carboxylate

There total 9 articles about ethyl 6-([tert-butyl(diphenyl)silyl]oxy)-9-(cyclopropylmethoxy)-benzo[h]quinoline-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 958219-71-1
6-([tert-butyl(diphenyl)silyl]oxy)-2-chloro-9-(cyclopropylmethoxy)benzo[h]quinoline

: 64-17-5
ethanol

: 201230-82-2
carbon monoxide

: 958219-76-6
ethyl 9-(cyclopropylmethoxy)-6-hydroxybenzo[h]quinoline-2-carboxylate

: 958219-75-5
ethyl 6-([tert-butyl(diphenyl)silyl]oxy)-9-(cyclopropylmethoxy)-benzo[h]quinoline-2-carboxylate

Guidance literature:: With triethylamine; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; In N,N-dimethyl-formamide; at 90 ℃; for 3h; Product distribution / selectivity;

Reference yield:

: 958219-61-9
2-chloro-9-methoxybenzo[h]quinolin-6-ol

: 958219-75-5
ethyl 6-([tert-butyl(diphenyl)silyl]oxy)-9-(cyclopropylmethoxy)-benzo[h]quinoline-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 36 h / 20 °C

2: boron tribromide; triethylamine / 1,1-dichloroethane / 5.67 h / -10 - 20 °C

3: di-tert-butyl-diazodicarboxylate; triphenylphosphine / tetrahydrofuran / 3 h / 20 °C

4: triethylamine / 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate / N,N-dimethyl-formamide / 3 h / 90 °C

With 1H-imidazole; di-tert-butyl-diazodicarboxylate; boron tribromide; triethylamine; triphenylphosphine; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; In tetrahydrofuran; 1,1-dichloroethane; N,N-dimethyl-formamide; 3: Mitsunobu reaction;

Reference yield:

: 958219-65-3
methyl [6-chloro-2-(3-methoxyphenyl)pyridine-3-yl]acetate

: 958219-75-5
ethyl 6-([tert-butyl(diphenyl)silyl]oxy)-9-(cyclopropylmethoxy)-benzo[h]quinoline-2-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: methanol; sodium hydroxide; water / tetrahydrofuran / 0.33 h / 0 - 20 °C

2: triethylamine / tetrahydrofuran / 19 h / Heating / reflux

3: aluminum (III) chloride / dichloromethane / 0.5 h / 70 °C

4: 1H-imidazole / N,N-dimethyl-formamide / 36 h / 20 °C

5: boron tribromide; triethylamine / 1,1-dichloroethane / 5.67 h / -10 - 20 °C

6: di-tert-butyl-diazodicarboxylate; triphenylphosphine / tetrahydrofuran / 3 h / 20 °C

7: triethylamine / 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate / N,N-dimethyl-formamide / 3 h / 90 °C

With 1H-imidazole; methanol; sodium hydroxide; di-tert-butyl-diazodicarboxylate; water; boron tribromide; triethylamine; triphenylphosphine; aluminum (III) chloride; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; In tetrahydrofuran; 1,1-dichloroethane; dichloromethane; N,N-dimethyl-formamide; 6: Mitsunobu reaction;